Evidence map›Paper›PMID 41664708›Full record

ArticleMedComm2026

Dysregulation of Farnesoid X Receptor on Neutrophil Homeostasis Exacerbates Intestinal Inflammation via the mTORC1-Glycolysis Signaling Pathway.

Dengfeng Kang, Ai Li, Xiangqi Xie, Han Liu, Liang Chen, Zhongsheng Feng, Xiang Gao, Han Gao, Xiaohan Wu, Huiying Lu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Dengfeng KangCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Ai LiCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Xiangqi XieCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Han LiuDepartment of Gastroenterology Qilu Hospital of Shandong University Jinan China.
Liang ChenCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Zhongsheng FengCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Xiang GaoCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Han GaoCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Xiaohan WuCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Huiying LuCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Xiaoyu LiCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Jinghan HuaCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Long JuCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.
Haifeng LianDepartment of Gastroenterology The Affiliated Yantai Yuhuangding Hospital of Qingdao University Yantai China.
Xue LiDepartment of Big Data in Health Science School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China.
Zhanju LiuCenter for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils significantly accumulate within the inflamed intestinal mucosa of patients with inflammatory bowel disease (IBD), where the farnesoid X receptor (FXR) is typically downregulated. However, the mechanisms by which FXR modulates neutrophil-mediated mucosal inflammation in IBD remain elusive. Here, we demonstrated that FXR expression is markedly decreased in neutrophils from patients with active IBD.

Indexed as

farnesoid X receptorinflammatory bowel diseasemucosal homeostasisneutrophil

Identifiers

PMID41664708
PMCPMC12883035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.