ArticleCytoJournal2025
A novel candidate tumor biomarker progestin and adipoQ receptor 3 regulates cell metastasis through transforming growth factor-β pathway in hepatocellular carcinoma.
Article in CytoJournal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- PCK2 Inhibition Reverses Cisplatin Resistance of Non-Small Cell Lung Cancer by Triggering Ferroptosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
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3 authors.
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Abstract
Objective: Progestin and adipoQ receptor 3 (PAQR3) have been identified as a potential tumor suppressor in hepatocellular carcinoma (HCC), yet its role in metastasis remains unclear. This study examined PAQR3 expression in primary HCC and its regulation of cell metastasis and ferroptosis through the transforming growth factor-b (TGF-b) pathway. Material and Methods: PAQR3 expression in HCC tissues was evaluated by immunohistochemistry, while western blotting (WB) and quantitative real-time polymerase chain reaction were used to assess its levels in HCC cells. Cell migration and invasion were analyzed using Transwell and wound-healing assays. WB was employed to measure epithelial-mesenchymal transition-related proteins. Ferroptosis was evaluated by measuring lipid peroxidation, iron accumulation, reactive oxygen species (ROS) levels, and the expression of ferroptosis-related proteins. Results: PAQR3 expression was significantly downregulated in HCC tissues and may serve as a prognostic marker ( Conclusion: These findings suggest that PAQR3 inhibits metastasis and induces ferroptosis in HCC through TGF-b pathway regulation.
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