Evidence map›Paper›PMID 41664690›Full record

ArticleRegenerative biomaterials2026

Stiff matrix drives microglial cell migration through Piezo1/Ca

Xinlan Chen, Zhongchen Li, Junqi Men, Hui Shao, Juncheng Bai, Yingying Guo, Xing Chen, Yubo Fan, Lin-Hua Jiang, Xiaoling Jia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinlan ChenKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, and with the School of Engineering Medicine, Beihang University, Beijing 100191, China.
Zhongchen LiDepartment of Neurosurgery, Liaocheng People's Hospital, Liaocheng 252000, China.
Junqi MenKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, and with the School of Engineering Medicine, Beihang University, Beijing 100191, China.
Hui ShaoKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, and with the School of Engineering Medicine, Beihang University, Beijing 100191, China.
Juncheng BaiKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, and with the School of Engineering Medicine, Beihang University, Beijing 100191, China.
Yingying GuoKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, and with the School of Engineering Medicine, Beihang University, Beijing 100191, China.
Xing ChenKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, and with the School of Engineering Medicine, Beihang University, Beijing 100191, China.
Yubo FanKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, and with the School of Engineering Medicine, Beihang University, Beijing 100191, China.ORCID https://orcid.org/0000-0002-3480-4395
Lin-Hua JiangDepartment of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province, Henan Key Laboratory of Neurorestoratology and Protein Modification, The First Affiliated Hospital, Henan Medical University, Xinxiang 453003, China.
Xiaoling JiaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, and with the School of Engineering Medicine, Beihang University, Beijing 100191, China.ORCID https://orcid.org/0000-0001-5806-7273

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The local stiffness of brain tissues increases in pathological states, and then, drives microglial cells to migrate towards stiffer areas for their functioning, but the underlying mechanism is still unclear. Herein, we investigated the role and mechanism of the mechanosensitive Piezo1 channel in matrix stiffness regulation of microglial cell migration using BV2 microglial cell line and mouse primary microglial cells growing on soft (500 Pa) and stiff (20 kPa) polyacrylamide (PA) hydrogels. Compared with soft substrates, stiff substrates promoted cell migration, upregulated the Piezo1 expression, raised intracellular Ca

Indexed as

F-actin reassemblymicroglial cellsmigrationPiezo1 channelsubstrate stiffness

Identifiers

PMID41664690
PMCPMC12883088

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.