Evidence map›Paper›PMID 41664460›Full record

ArticleRestorative dentistry & endodontics2026

Comparative evaluation of dentinal tubule occlusion by desensitizing agents after tooth bleaching: an in vitro study.

Dimitrios Dionysopoulos, Petros Mourouzis, Spyros Papageorgiou, Kosmas Tolidis

Abstract read
In one paragraph

Article in Restorative dentistry & endodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dimitrios DionysopoulosDepartment of Operative Dentistry, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Petros MourouzisDepartment of Operative Dentistry, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Spyros PapageorgiouLaboratory of Chemistry-Biochemistry-Cosmetic Science, Department of Biomedical Sciences, University of West Attica, Athens, Greece.
Kosmas TolidisDepartment of Operative Dentistry, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Funding

Aristotle University of Thessaloniki 10468
6 · The paper itself

Abstract

Objectives: : This study aimed to evaluate the efficacy of three commercially available desensitizing agents in occluding dentinal tubules, which may help reduce tooth sensitivity following a bleaching treatment. Methods: Twenty healthy human third molars were utilized in this investigation. The samples were prepared by transversely sectioning 2.5 mm of the crowns to expose the dentin. They were initially treated with 15% ethylenediaminetetraacetic acid gel for 4 minutes, followed by application of Perfect Bleach (VOCO GmbH) bleaching agent (16% carbamide peroxide) for 2 hours. The samples were randomly allocated into four groups (n = 5), each receiving one of the following treatments: group 1: No treatment (control), group 2: treated with UltraEZ (Ultradent Products Inc.,), containing potassium nitrate and sodium fluoride, group 3: treated with Perfect Protect (VOCO GmbH), also containing potassium nitrate and sodium fluoride and group 4: treated with TheraSol Whitening & Sensitive (ABC Kinitron IKE), containing strontium acetate and sodium monofluorophosphate. Subsequently, the specimens were examined using scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy to evaluate dentin tubule occlusion. Results: SEM observations showed no occlusion of dentin tubules in the control group, whereas groups 2 to 4 exhibited significant occlusion. The most effective treatment was Perfect Protect (p < 0.05), while UltraEZ and TheraSol Whitening & Sensitive demonstrated similar effectiveness, with no statistically significant difference between them (p > 0.05). Conclusions: The tested desensitizing agents effectively occluded dentin tubules to a considerable extent. Differences in their effectiveness were attributed to variations in their formulations.

Indexed as

Protect dentin desensitizerScanning electron microscopyTooth bleachingX-ray emission spectrometry

Identifiers

PMID41664460
PMCPMC12989807

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.