Evidence map›Paper›PMID 41664259›Full record

SynthesisJournal of occupational and environmental medicine2026

Understanding the Endocrine and Reproductive Health Effects Associated With Exposures to Jet Fuels: A Fit-for-Purpose Systematic Literature Review.

Lisa M Prince, Rochelle L Cameron, Dylan J Jester, Mehret T Assefa, Halee Staggs, Maheen M Adamson, Samantha J Goodman, Samantha J Snow, Sorina E Eftim, Terra D Vincent-Hall

Abstract readSystematic Review
In one paragraph

Synthesis in Journal of occupational and environmental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lisa M PrinceFrom the ICF, Reston, VA (L.M.P., S.J.G., S.J.S., S.E.E.); Exposure Science Program, Health Outcomes Military Exposures, Department of Veterans Affairs, Washington, DC (R.L.C., T.D.V.H.); Women's Operational and Military Exposure Network Center of Excellence (WOMEN CoE), VA Palo Alto Health Care System, Palo Alto, CA (D.J.J., M.T.A., H.S., M.M.A.); and Neurosurgery, Stanford University School of Medicine, Stanford, CA (M.M.A.).ORCID 0000-0001-6966-3564
Rochelle L CameronORCID 0009-0007-4354-8251
Samantha J GoodmanORCID 0000-0003-4828-0964
Terra D Vincent-HallORCID 0009-0000-4218-4010

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the study was to assess the endocrine and reproductive health effects associated with jet fuels used by the US military.

methodsA systematic review of epidemiologic, animal toxicological, and mechanistic studies was conducted, synthesizing evidence on endocrine and reproductive outcomes following jet fuel exposure.

resultsEpidemiologic studies on endocrine and reproductive outcomes yielded indeterminate evidence, with no endocrine studies and inconsistent findings on menstrual abnormalities, sex hormone concentrations, and sperm parameters. Animal toxicological studies provided slight evidence for changes in endocrine organs, including observations of adrenal gland histopathology and weight alterations. Animal data provided slight evidence for reproductive health, with histopathological findings of mammary gland hyperplasia in females and testis atrophy in males.

conclusionsEvidence suggests that potential endocrine and reproductive toxicity may result from jet fuel exposure. Additional research is needed to better understand these relationships.

Indexed as

HydrocarbonsAnimalsFemaleHumansMaleReproductionReproductive HealthTestisHydrocarbonsJP8 aviation fueladrenalendocrine effectshormonal disruptionjet fuelsreproductive toxicitytestis atrophy

Identifiers

PMID41664259
PMCPMC12928820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.