ArticleMolecular cancer2026
Tumour-infiltrating microplastics disrupt the JAK-STAT-microbiota axis to promote immunotherapy resistance in colorectal cancer.
Article in Molecular cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Microplastic-Mediated Gene Expression Alterations and Cancer Risk: Insights from Toxicogenomic Analysis.International journal of molecular sciences · 2026Review
- Molecular pathways linking the gut microbiome to antitumor immunity.Trends in microbiology · 2026Review
- Micro- and Nanoplastics as Environmental Stressors: Mechanistic Links Among Gut Dysbiosis, Inflammation, and Systemic Health Effects.Journal of xenobiotics · 2026Review
- Dietary Intake of Micro- and Nanoplastics: Potential Adverse GI Effects on Microbiome, Inflammation, and Neoplasia.Microorganisms · 2026Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Microplastics are pervasive global environmental pollutants. While their potential health impacts are acknowledged, their link to cancer remains unclear. The colorectum is the primary microplastics absorption site and further exploration of the effects of microplastics on colorectal cancer progression and immunotherapy efficacy are warranted. In this study, microplastics were isolated from colorectal cancer tumour tissues and blood, and their properties were examined. microplastics worsened colorectal cancer severity and promoted immunotherapy resistance in animal models. Moreover, microplastics uptake inhibited the JAK-STAT pathway; downregulated IFN-γ, CXCL9, CXCL11, B2m, and H2-K1 expression; decreased CD8+ and CD4+ T-cell infiltration; and increased tumour resistance to immunotherapy. Microplastics also triggered gut microbiota dysbiosis, significantly contributing to colorectal cancer immunotherapy resistance. Microplastics play an important role in colorectal cancer immunotherapy resistance by altering the tumour immune microenvironment and represent a novel target in colorectal cancer immunotherapy, especially amid increasing microplastics pollution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.