Evidence map›Paper›PMID 41664170›Full record

ArticleTrials2026

Digital cognitive-behavioral therapy for pain management in individuals with recurrent acute and chronic pancreatitis (IMPACT-2): study protocol for a hybrid effectiveness-implementation trial.

Tonya M Palermo, Olivia Ohls, Blake Dear, Ardith Z Doorenbos, Dhiraj Yadav, Chuan Zhou, Melena Bellin, William Fisher, Evan Fogel, Christopher Forsmark and 5 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06386224 (Internet-Delivered Pain Self-Management to Reduce Pain and Interference in Chronic Pancreatitis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06386224 narecruitingnot on this map

Internet-Delivered Pain Self-Management to Reduce Pain and Interference in Chronic Pancreatitis

TypeinterventionalSponsorSeattle Children's HospitalRan2024 to 2028Enrolled280ConditionsPancreatitis, Chronic Pancreatitis, Acute Recurrent PancreatitisArmsInternet-delivered pain self-management (CBT Condition), Education Program
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tonya M PalermoDepartment of Anesthesiology & Pain Medicine, University of Washington School of Medicine, Seattle, USA. tonya.palermo@seattlechildrens.org.ORCID http://orcid.org/0000-0001-6036-6715
Olivia OhlsCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, USA.
Blake DearSchool of Psychological Sciences, Macquarie University, Sydney, Australia.
Ardith Z DoorenbosCollege of Nursing, University of Illinois Chicago, Chicago, USA.
Dhiraj YadavDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, USA.
Chuan ZhouCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, USA.
Melena BellinDepartment of Pediatrics, University of Minnesota, Minneapolis, USA.
William FisherDepartment of Surgery, Baylor College of Medicine, Houston, USA.
Evan FogelDepartment of Medicine, Indiana University Health, Indianapolis, USA.
Christopher ForsmarkDepartment of Medicine, University of Florida, Gainesville, USA.
Phil A HartDepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, USA.
Walter G ParkDepartment of Medicine-Gastroenterology & Hepatology, Stanford University School of Medicine, Stanford, USA.
Stephen PandolDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, USA.
Guru TrikudanathanDepartment of Medicine-Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, USA.
Darwin L ConwellDepartment of Internal Medicine, University of Kentucky, Lexington, USA.

Funding

Internet-Delivered Pain Self-Management to Reduce Pain and Interference in Chronic PancreatitisR01DK137520 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI DARWIN LEWIS CONWELL, Tonya M Palermo · 2023 to 2026
$3.0M
NIDDK NIH HHS R01 DK137520NIDDK NIH HHS R01DK137520
6 · The paper itself

Abstract

backgroundAbdominal pain is a cardinal symptom of pancreatitis, present in up to 90% of patients with recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP). Increases in pain severity and constancy are associated with significant morbidity including depression and anxiety symptoms, low physical functioning, sleep disturbance, and low quality of life, as well as high economic and societal burden. Our pilot study of digital cognitive-behavioral therapy (CBT) demonstrated preliminary efficacy in improving pain and disability in adults with recurrent acute and chronic pancreatitis pain. Building on these promising findings, this hybrid effectiveness-implementation clinical trial seeks to test the effectiveness of digital CBT in a large sample and to gather data on future implementation of this scalable intervention.

methodsThis multisite, pragmatic clinical trial is recruiting 280 adults (ages 18 +) with recurrent acute or chronic pancreatitis who report chronic pain. Participants are randomized 1:1 respectively to one of two groups: (1) Digital CBT, providing access to the Pancreatitis Pain Course to learn pain self-management skills (e.g., relaxation, activity pacing, goal setting), or (2) Digital Pain Education (access to education website about pancreatitis pain). Evaluations are completed at baseline, 2 months, and 6 months follow up. This study leverages resources of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC), a NIH-sponsored U01 consortium, with recruitment from their nine clinical centers and from self-referral in the community through partnerships with community-based and clinical organizations. Relevant stakeholder groups (patients, providers, organizational managers) will participate in a process evaluation to inform future implementation in clinic and community settings. Primary effectiveness outcomes are pain interference and severity. Secondary outcomes include opioid use, depression, anxiety, quality of life, and sleep. DISCUSSION: Findings from the IMPACT-2 trial will significantly advance solutions for non-pharmacological pain management in RAP and CP. If successful, our project will address a critical need for low-cost, accessible pain self-management.

trial registrationNCT06386224 ; first posted: 04-26-2024.

Indexed as

Abdominal PainChronic PainCognitive Behavioral TherapyPain ManagementPancreatitisPancreatitis, ChronicAcute DiseaseHumansMulticenter Studies as TopicPain MeasurementPatient Education as TopicPilot ProjectsPragmatic Clinical Trials as TopicQuality of LifeRandomized Controlled Trials as TopicRecurrenceChronic pancreatitisCognitive-behavioral therapyDigital interventionPain managementRandomized controlled trialRecurrent acute pancreatitis

Identifiers

PMID41664170
PMCPMC12983583

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.