A Versatile Engineering Platform for the Fabrication of Prosthetic Venous Valves Using Electrospinning.

Dario Arcuti, Salma Mansi, Dominic Biebl, Malin Reuter, Maximilian Grab, José Carlos Rodríguez-Cabello, Petra Mela

Abstract read

In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Bioinspired functional materials for biomedical applications.Frontiers in bioengineering and biotechnology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dario ArcutiTUM School of Engineering and Design, Department of Mechanical Engineering, Chair of Medical Materials and Implants, Munich Institute of Biomedical Engineering, Technical University of Munich, Germany, Munich Institute of Integrated Materials, Energy and Process Engineering, Garching, Germany.ORCID https://orcid.org/0000-0003-3447-7977

Salma MansiTUM School of Engineering and Design, Department of Mechanical Engineering, Chair of Medical Materials and Implants, Munich Institute of Biomedical Engineering, Technical University of Munich, Germany, Munich Institute of Integrated Materials, Energy and Process Engineering, Garching, Germany.ORCID https://orcid.org/0000-0001-5052-9840

Dominic BieblTUM School of Engineering and Design, Department of Mechanical Engineering, Chair of Medical Materials and Implants, Munich Institute of Biomedical Engineering, Technical University of Munich, Germany, Munich Institute of Integrated Materials, Energy and Process Engineering, Garching, Germany.ORCID https://orcid.org/0009-0009-9778-9151

Malin ReuterTUM School of Engineering and Design, Department of Mechanical Engineering, Chair of Medical Materials and Implants, Munich Institute of Biomedical Engineering, Technical University of Munich, Germany, Munich Institute of Integrated Materials, Energy and Process Engineering, Garching, Germany.

Maximilian GrabTUM School of Engineering and Design, Department of Mechanical Engineering, Chair of Medical Materials and Implants, Munich Institute of Biomedical Engineering, Technical University of Munich, Germany, Munich Institute of Integrated Materials, Energy and Process Engineering, Garching, Germany.ORCID https://orcid.org/0000-0002-3158-9095

José Carlos Rodríguez-CabelloBioforge Lab (Group For Advanced Materials and Nanobiotechnology), Laboratory For Disruptive Interdisciplinary Science (LaDIS), CIBER-BBN, Edificio LUCIA, Universidad De Valladolid, Valladolid, Spain.

Petra MelaTUM School of Engineering and Design, Department of Mechanical Engineering, Chair of Medical Materials and Implants, Munich Institute of Biomedical Engineering, Technical University of Munich, Germany, Munich Institute of Integrated Materials, Energy and Process Engineering, Garching, Germany.ORCID https://orcid.org/0000-0001-6503-076X

Funding

ERDF MCIN/AEI/10.13039/501100011033J.C.R.-C. is grateful for funding from the Spanish Government PID2022-137484OB-I00the Junta de Castilla y León VA188P23

6 · The paper itself

Abstract

Chronic venous insufficiency caused by valvular incompetence affects millions. Yet, functional prosthetic venous valves (PVVs) remain elusive. Previous concepts failed due to thrombosis and leaflet thickening caused by vascular cell hyperplastic overgrowth. Here, we address these issues by developing a fabrication platform for percutaneous PVVs by fully embedding the stent struts in electrospun fibers that extend luminally to form thin leaflets. This approach offers unique advantages: the electrospun matrix, with spatially controlled porosity, separates the leaflets from hyperproliferating vascular cells and the stent struts from the blood. Its continuity with the leaflets eliminates the need for anchoring points on the stent and associated fixation methods. As a result, stents of any type, cell design or length can be employed, with valve placement possible at any position. We demonstrate these benefits by fabricating bicuspid valves using segments of commercial stents and either single or multiple materials via dual electrospinning, such as thermoplastic polyurethane (TPU) lined with elastin-like recombinamers (ELRs). The ELR/TPU constructs exhibit minimal platelet adhesion, no hemolysis, and support endothelialization in vitro. Functional evaluation confirms excellent hydrodynamic performance. Finally, the platform's potential for other applications is shown with tricuspid small diameter pediatric heart valves successfully tested according to ISO 8540.

Indexed as

Heart Valve ProsthesisTissue EngineeringVenous ValvesAnimalsElastinHumansPlatelet AdhesivenessPolyurethanesProsthesis DesignStentsElastinPolyurethaneschronic venous insufficiencydual electrospinningelastin‐like recombinamerssmall‐diameter heart valvesvascular valvesvenous valves

Identifiers

PMID41664157

DOI10.1002/adhm.202504851

PMCPMC13107922

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.