Evidence map›Paper›PMID 41663835›Full record

ArticleBulletin of experimental biology and medicine2025

Anastasis: Reality or Fiction?

Y S Kim, K V Kovalskaya, S L Malov, G V Manukyan, R V Kholodenko, K N Yarygin, I V Kholodenko

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Y S KimInstitute of Biomedical Chemistry, Moscow, Russia.
K V KovalskayaInstitute of Biomedical Chemistry, Moscow, Russia.
S L MalovPetrovsky National Research Centre of Surgery, Moscow, Russia.
G V ManukyanPetrovsky National Research Centre of Surgery, Moscow, Russia.
R V KholodenkoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
K N YaryginInstitute of Biomedical Chemistry, Moscow, Russia.
I V KholodenkoInstitute of Biomedical Chemistry, Moscow, Russia. irkhol@yandex.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased resistance to the apoptosis-inducing stimuli, as well as the reversibility of the process of cell death, are currently recognized as the mechanisms that tumor cells use for survival, maintenance of malignancy, and metastasis. The term "anastasis" was introduced to describe the reversibility of cell death. We have previously shown that mesenchymal stem cells (MSCs) are resistant to receptor-mediated apoptosis. In this work, the possibility of anastasis in three types of mesenchymal cells (human liver and placental MSCs and skin fibroblasts) was studied after exposure to common cell death inducers ethanol, staurosporine, or doxorubicin. We have shown that restoration of cell morphology and proliferation occurs after treatment with non-lethal doses of ethanol and low concentration of doxorubicin, while staurosporine at non-lethal concentrations produces an irreversible cytostatic effect.

Indexed as

ApoptosisDoxorubicinEthanolFibroblastsMesenchymal Stem CellsStaurosporineCell ProliferationFemaleHumansLiverPlacentaPregnancySkinDoxorubicinEthanolStaurosporineanastasisapoptosiscell deathmesenchymal stem cellsskin fibroblasts

Identifiers

PMID41663835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.