Evidence map›Paper›PMID 41663780›Full record

ArticleDiscover oncology2026

JAG1 expression in papillary thyroid cancer stem-like cells predicts poor prognosis and implicates angiogenesis.

Riho Yoshida-Minato, Tetsuhiro Horie, Mitsuharu Aga, Takuya Sakamoto, Akiko Inujima, Yuka Nakamura, Kazuo Yasumoto, Yasuhito Ishigaki, Takaki Miwa, Hideaki Shiga

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In one paragraph

Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Riho Yoshida-Minato *Department of Otorhinolaryngology, Kanazawa Medical University, Kahoku, 920-0293, Ishikawa, Japan.
Tetsuhiro Horie *Medical Research Institute, Kanazawa Medical University, Kahoku, 920-0293, Ishikawa, Japan.
Mitsuharu AgaDepartment of Otorhinolaryngology, Kanazawa Medical University, Kahoku, 920-0293, Ishikawa, Japan.
Takuya SakamotoMedical Research Institute, Kanazawa Medical University, Kahoku, 920-0293, Ishikawa, Japan.
Akiko InujimaDepartment of Medical Oncology, Kanazawa Medical University, Kahoku, 920-0293, Ishikawa, Japan.
Yuka NakamuraMedical Research Institute, Kanazawa Medical University, Kahoku, 920-0293, Ishikawa, Japan.
Kazuo YasumotoDepartment of Medical Oncology, Kanazawa Medical University, Kahoku, 920-0293, Ishikawa, Japan.
Yasuhito IshigakiMedical Research Institute, Kanazawa Medical University, Kahoku, 920-0293, Ishikawa, Japan.
Takaki MiwaDepartment of Otorhinolaryngology, Kanazawa Medical University, Kahoku, 920-0293, Ishikawa, Japan.
Hideaki ShigaDepartment of Otorhinolaryngology, Kanazawa Medical University, Kahoku, 920-0293, Ishikawa, Japan. shigah@kanazawa-med.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThyroid cancer stem cells (CSCs) have been implicated in the recurrence and metastasis of thyroid cancer. This study, therefore, explored the properties of thyroid CSC-like cells, cell-cell interactions, and genes associated with prognosis by analyzing single-cell RNA sequencing (scRNA-seq) data and clinical data.

methodsWe analyzed two independent scRNA-seq datasets (GSE191288 and GSE250521) using the Seurat R package. Tumor cells were identified based on copy number variations, and stemness

resultsCompared to stemness

conclusionsThis study provides new insights into the gene expression profile of thyroid CSC-like cells and their interactions with cells constituting tumor tissues.

Identifiers

PMID41663780
PMCPMC12988114

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