Evidence map›Paper›PMID 41663744›Full record

ArticleNature biomedical engineering2026

X-ray activated platinum complex induces DNA damage and enhances cancer immunotherapy through abscopal effect.

Guiyuan Chen, Xiangxia Li, Yu Huang, Cheng Zheng, Haopeng Fang, Qiaoyun Zhang, Ke Liu, Kecheng Wu, Qilong Zhu, Changqing Guo and 16 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Guiyuan ChenDepartment of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Hefei National Research Center for Physical Sciences at the Microscale; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China.ORCID http://orcid.org/0000-0001-7623-651X
Xiangxia LiDepartment of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Hefei National Research Center for Physical Sciences at the Microscale; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Yu HuangKey Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China.ORCID http://orcid.org/0000-0002-1936-1987
Cheng ZhengSchool of Physical Sciences and Ion Medical Research Institute, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Haopeng FangDepartment of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Qiaoyun ZhangDepartment of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Ke LiuDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P. R. China.ORCID http://orcid.org/0009-0003-4948-2119
Kecheng WuDepartment of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Hefei National Research Center for Physical Sciences at the Microscale; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Qilong ZhuDepartment of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Hefei National Research Center for Physical Sciences at the Microscale; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Changqing GuoDepartment of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Hefei National Research Center for Physical Sciences at the Microscale; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Huanjun ZhuDepartment of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Hefei National Research Center for Physical Sciences at the Microscale; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Ruike DaiDepartment of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Hefei National Research Center for Physical Sciences at the Microscale; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Ying HeDepartment of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Hefei National Research Center for Physical Sciences at the Microscale; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Qiuhong ZhuIntelligent Pathology Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Wenchao ZhouIntelligent Pathology Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P. R. China.ORCID http://orcid.org/0000-0002-6650-1831
Yidong YangSchool of Physical Sciences and Ion Medical Research Institute, University of Science and Technology of China, Hefei, Anhui, P. R. China.
Zibo LiBiomedical Research Imaging Center, Department of Radiology, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-1063-0298
Kun QuDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P. R. China. qukun@ustc.edu.cn.ORCID http://orcid.org/0000-0002-5555-8437
Bofeng LiDepartment of Medical Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, P. R. China. libf@ustc.edu.cn.ORCID http://orcid.org/0000-0002-9110-8804
Shiyan XiaoKey Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China. xiaosy@ustc.edu.cn.ORCID http://orcid.org/0000-0003-1159-1224
Shaomin TianDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Bengang XingSchool of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore.ORCID http://orcid.org/0000-0002-8391-1234
Xiaoyuan ChenDepartments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-9622-0870
Andrew Z WangDepartment of Radiation Oncology, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-9781-4494
Yujie XiongSchool of Chemistry and Materials Science, Experimental Center of Engineering and Material Sciences, School of Engineering Science, University of Science and Technology of China, Hefei, Anhui, P. R. China.ORCID http://orcid.org/0000-0002-1995-8257
Yuanzeng MinDepartment of Endocrinology and Metabolism, Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; Hefei National Research Center for Physical Sciences at the Microscale; Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, P. R. China. minyz@ustc.edu.cn.ORCID http://orcid.org/0000-0001-5030-0210

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotherapy is used in more than half of cancer patients, yet most radiosensitizers increase reactive oxygen species (ROS) to enhance cytotoxicity in treated cells. This approach has limited use in hypoxic tumours and may cause oxidative injury to healthy tissues. We developed a platinum(II) azido complex (Complex 1) that releases platinonitrene upon X-ray exposure. Platinonitrene reacts with nucleophilic sites on DNA bases, forming covalent adducts that disrupt DNA integrity and cause double-strand breaks, leading to tumour cell death through a mechanism distinct from classical platinum coordination. Computational modelling elucidated this pathway and supported its role in radiosensitization. Complex 1 was synthesized by sequential ligand exchange of potassium tetrachloroplatinate with cyclohexanediamine, silver nitrate and sodium azide. In murine models, complex 1 showed negligible toxicity to major organs and normal immune cells while selectively reducing regulatory T-cell infiltration in tumours. Combined with low-dose radiotherapy and programmed cell death protein 1 blockade, it achieved complete regression of bilateral tumours in 40% of mice, demonstrating a strong abscopal effect. This work establishes metallonitrene-based, ROS-independent radiosensitization for precision radiotherapy.

Identifiers

PMID41663744

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