Evidence map›Paper›PMID 41663718›Full record

ArticleCommunications biology2026

Environmentally relevant lanthanum chloride exposure induces hepatic steatosis in zebrafish larvae via PPARα-dependent ApoB suppression.

Keying Li, Xinying Zhao, Zhuoyi Xie, Qiuchen Wu, Wenlu Jia, Xiangrong Zhou, Xiang Gao, Ping Zeng, Jing Li, Qiao Niu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Keying Li *Key Laboratory of Human Genetics and Environmental Medicine, Key Laboratory of Environment and Health, Center for Medical Statistics and Data Analysis, Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, China.
Xinying Zhao *Key Laboratory of Human Genetics and Environmental Medicine, Key Laboratory of Environment and Health, Center for Medical Statistics and Data Analysis, Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, China.
Zhuoyi XieKey Laboratory of Human Genetics and Environmental Medicine, Key Laboratory of Environment and Health, Center for Medical Statistics and Data Analysis, Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, China.
Qiuchen WuKey Laboratory of Human Genetics and Environmental Medicine, Key Laboratory of Environment and Health, Center for Medical Statistics and Data Analysis, Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, China.
Wenlu JiaJiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, China.
Xiangrong ZhouKey Laboratory of Human Genetics and Environmental Medicine, Key Laboratory of Environment and Health, Center for Medical Statistics and Data Analysis, Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, China.
Xiang GaoKey Laboratory of Human Genetics and Environmental Medicine, Key Laboratory of Environment and Health, Center for Medical Statistics and Data Analysis, Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, China.
Ping ZengKey Laboratory of Human Genetics and Environmental Medicine, Key Laboratory of Environment and Health, Center for Medical Statistics and Data Analysis, Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, China.ORCID http://orcid.org/0000-0003-2710-3440
Jing LiKey Laboratory of Human Genetics and Environmental Medicine, Key Laboratory of Environment and Health, Center for Medical Statistics and Data Analysis, Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, China.
Qiao NiuKey Laboratory of Human Genetics and Environmental Medicine, Key Laboratory of Environment and Health, Center for Medical Statistics and Data Analysis, Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, China.
Zhipeng QiKey Laboratory of Human Genetics and Environmental Medicine, Key Laboratory of Environment and Health, Center for Medical Statistics and Data Analysis, Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, China.
Mengqiao CuiJiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, China.ORCID http://orcid.org/0000-0002-7098-8718
Weiyi SongKey Laboratory of Human Genetics and Environmental Medicine, Key Laboratory of Environment and Health, Center for Medical Statistics and Data Analysis, Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, School of Public Health, Xuzhou Medical University, Xuzhou, China. songweiyi798@xzhmu.edu.cn.ORCID http://orcid.org/0000-0002-7635-7853

Funding

China Postdoctoral Science Foundation 2022M722675Jiangsu Science and Technology Department BK20220665National Natural Science Foundation of China (National Science Foundation of China) 82574127, 82204081, 42507576Natural Science Research of Jiangsu Higher Education Institutions of China 24KJB330011, 25KJB330009
6 · The paper itself

Abstract

Lanthanum (La), the second most produced rare earth element, is detected in various environmental and human samples. Epidemiological studies have reported a strong association between La exposure and liver injury. However, the effects of early La exposure on liver development and underlying mechanisms remain limited. Here, we evaluate the hepatotoxicity of LaCl

Indexed as

Apolipoproteins BFatty LiverLanthanumPPAR alphaZebrafishZebrafish ProteinsAnimalsLarvaLiverSignal TransductionApolipoproteins BLanthanumlanthanum chloridePPAR alphaZebrafish Proteins

Identifiers

PMID41663718
PMCPMC12996399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.