Evidence map›Paper›PMID 41663696›Full record

ReviewPituitary2026

Histopathological and radiological predictors of surgical remission failure in GH-secreting pituitary adenomas.

R Calandrelli, D De Lucia, S Chiloiro, A Vicari, P P Mattogno, F Valeri, M Gessi, F Doglietto, S Gaudino

Abstract readReview
PubMed Publisher
In one paragraph

Review in Pituitary, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Current treatment landscape of acromegaly.The Journal of clinical endocrinology and metabolism · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

R CalandrelliDepartment of Oncological Radiotherapy, and Hematology, ARC Advanced Radiology Center (ARC), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy. rosalinda.calandrelli@policlinicogemelli.it.
D De LuciaDepartment of Oncological Radiotherapy, and Hematology, ARC Advanced Radiology Center (ARC), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
S ChiloiroDepartment of of Medicine, Endocrinology and Diabetology, Fondazione Policlinico, Rome, Italy.
A VicariDepartment of of Medicine, Endocrinology and Diabetology, Fondazione Policlinico, Rome, Italy.
P P MattognoDepartment of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
F ValeriDepartment of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
M GessiCatholic University of the Sacred Heart, Rome, Italy.
F Doglietto *Catholic University of the Sacred Heart, Rome, Italy.
S Gaudino *Department of Oncological Radiotherapy, and Hematology, ARC Advanced Radiology Center (ARC), Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the role of T2 signal intensity in differentiating granulation patterns in GH-secreting pituitary adenomas and identify key radiological and histological predictors of surgical remission failure. 

methods107 GH-secreting pituitary adenomas were assessed for granulation patterns (DG, SG), tumor volume, normalized T2 signal intensity, extrasellar extension, and proliferative status. Patients were divided into two groups according to surgical remission status assessed at 6 months post-surgery. 

results52 pituitary adenomas were DG and 55 were SG, with T2 signal intensity distinguishing the two subtypes. Infrasellar extension was more common than suprasellar or parasellar extension in both subtypes, with no significant difference in surgical remission rates between SG and DG tumors (p = 0.098).Surgical-remission and non-remission groups differed in tumor volume (p = 0.018), vertical infrasellar extension (p = 0.002), and cavernous sinus invasiveness (p = 0.009). Tumors in non-surgical remission group had larger volumes (2043.33 mm³ vs. 1647.60 mm³), greater infrasellar extension (5mm vs. 2.75mm), and higher cavernous sinus invasiveness (47.3% vs. 32.1%). Infrasellar extension and cavernous sinus invasiveness were predictive of surgical remission failure (OR, 1.186; p = 0.005; OR, 2.997; p = 0.023); an infrasellar growth cutoff greater than 4.93 mm was identified as a potential radiological marker for surgical remission failure (58% sensitivity, 71% specificity, AUC = 0.67, p < 0.001). 

conclusionT2 signal intensity helps identify granulation patterns, but it does not predict surgical remission. Surgical remission failure is associated with cavernous sinus invasion and infrasellar extension greater than 4.93 mm, indicating more aggressive GH-secreting pituitary adenomas.

Indexed as

AdenomaGrowth Hormone-Secreting Pituitary AdenomaPituitary NeoplasmsAdultAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRemission InductionTreatment FailureTumor BurdenDensely granulated patternGH-secreting adenomasSparsely granulated patternSurgical remission failure

Identifiers

PMID41663696

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.