Evidence map›Paper›PMID 41663649›Full record

ArticleScientific reports2026

Association of 25-hydroxyvitamin D levels and vitamin D receptor gene polymorphisms with breast cancer risk in Bangladeshi women.

Raushanara Akter, Md Siddiqul Islam, Abu Syed Md Mosaddek, Md Waheed Akhtar, Afrina Afrose, Md Aminul Haque, Faruque Azam, Sabrina Sharmin, Raquibul Hasan, M Mahboob Hossain and 2 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Raushanara AkterSchool of Pharmacy, BRAC University, Kha 224 Bir Uttam Rafiqul Islam Avenue, Merul Badda, Dhaka, 1212, Bangladesh. raushanara@bracu.ac.bd.
Md Siddiqul IslamDepartment of Pharmacy, American International University-Bangladesh, Dhaka, Bangladesh.
Abu Syed Md MosaddekDepartment of Pharmacology, Uttara Adhunik Medical College, Dhaka, Bangladesh.
Md Waheed AkhtarDepartment of Radiotherapy, Sir Salimullah Medical College, Dhaka, Bangladesh.
Afrina AfroseSchool of Pharmacy, BRAC University, Kha 224 Bir Uttam Rafiqul Islam Avenue, Merul Badda, Dhaka, 1212, Bangladesh.
Md Aminul HaqueSchool of Pharmacy, BRAC University, Kha 224 Bir Uttam Rafiqul Islam Avenue, Merul Badda, Dhaka, 1212, Bangladesh.
Faruque AzamSchool of Pharmacy, BRAC University, Kha 224 Bir Uttam Rafiqul Islam Avenue, Merul Badda, Dhaka, 1212, Bangladesh.
Sabrina SharminSchool of Pharmacy, BRAC University, Kha 224 Bir Uttam Rafiqul Islam Avenue, Merul Badda, Dhaka, 1212, Bangladesh.
Raquibul HasanDepartment of Pharmaceutical Sciences, Mercer University, Atlanta, USA.
M Mahboob HossainDepartment of Microbiology, BRAC University, Dhaka, Bangladesh.
Ranjan Kumar BhowmickDepartment of Radiation Oncology, NICRH, Dhaka, Bangladesh.
Muhammad AsaduzzamanSchool of Pharmacy, BRAC University, Kha 224 Bir Uttam Rafiqul Islam Avenue, Merul Badda, Dhaka, 1212, Bangladesh.

Funding

BRAC University RSGI 2023
6 · The paper itself

Abstract

Breast cancer (BrCa) is a leading cause of mortality among Bangladeshi women. Deficiency of 25-hydroxyvitamin D [25(OH)D] and vitamin D receptor (VDR) polymorphisms have been linked to cancer susceptibility, but evidence from South Asia is scarce. We conducted a case-control study of 400 BrCa patients and 400 age-matched controls to assess serum 25(OH)D levels and four VDR variants (rs731236, rs2228570, rs1544410, rs7975232) in relation to BrCa risk. Logistic regression showed significant associations for rs2228570 (FokI; odds ratio [OR] 1.52, 95% confidence interval [CI] 1.14-2.02, p = 0.004) and rs1544410 (BsmI; OR 1.52, 95% CI 1.14-2.02, p = 0.0044) under dominant models, while rs731236 (TaqI) and rs7975232 (ApaI) showed no effect. Serum 25(OH)D levels were lower in cases than controls, with 80.7% of cases deficient; low 25(OH)D was associated with increased risk (OR 2.15, 95% CI 1.06-4.38, p = 0.035). No variant correlated with 25(OH)D levels. These findings suggest that FokI, BsmI, and low 25(OH)D independently contribute to BrCa risk in Bangladeshi women.

Indexed as

Breast NeoplasmsGenetic Predisposition to DiseasePolymorphism, Single NucleotideReceptors, CalcitriolVitamin DAdultBangladeshCase-Control StudiesFemaleHumansMiddle AgedRisk Factors25-hydroxyvitamin DReceptors, CalcitriolVDR protein, humanVitamin D

Identifiers

PMID41663649
PMCPMC12963494

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