Integrated Transcriptomic and Metabolomic Analyses Reveal Molecular Mechanism in Hybrid Crucian Carp (Carassius cuvieri♀ × Carassius auratus Red var♂) after Gut Infection with Aeromonas hydrophila L3-3.

Fei Wang, Wei-Sheng Luo, Zi-Le Qin, Jian Li, Si-Ze Xiao, Sheng-Wei Luo

Abstract read

In one paragraph

Article in Marine biotechnology (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

6 authors.

Fei Wang *Engineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, PR, 410081, China.

Wei-Sheng Luo *Engineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, PR, 410081, China.

Zi-Le QinEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, PR, 410081, China.

Jian LiEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, PR, 410081, China.

Si-Ze XiaoEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, PR, 410081, China.

Sheng-Wei LuoEngineering Research Center of Polyploidy fish Reproduction and Breeding of the State Education Ministry, College of Life Science, Hunan Normal University, Changsha, PR, 410081, China. swluo@hunnu.edu.cn.

Funding

Hunan Provincial Natural Science Foundation of China, China 2026JJ50145National Key Research and Development Program of China 2023YFD2401601National Natural Science Foundation of China, China 31902363Project Foundation of Changsha Science and Technology Bureau, China kq2502141Scientific Research Project of Hunan Provincial Department of Education, China 25B0071

6 · The paper itself

Abstract

Aeromonas hydrophila is an important etiologic agent that can pose a significant threat to the health of aquatic animals. Nonetheless, the immunometabolic crosstalk of hybrid crucian carp (WR, Carassius cuvieri♀ × Carassius auratus red var♂) after gut infection remains largely understudied. In this study, WRs receiving gut infection with A. hydrophila L3-3 displayed increased levels of tissue damage and antioxidant collapse. Then, multiomics analyses indicated that fatty acid metabolism may be considered as the crucial metabolic pathways in midgut of WRs following gut infection with A. hydrophila L3-3, with FFA(14:1) and Ser-Ile-Asn-Lys acting as pivotal biomarkers. These findings may clarify the immunometabolic response and identify the molecular regulatory mechanisms in gut tract of WRs after A. hydrophila L3-3 infection.

Indexed as

Aeromonas hydrophilaCarpsFish DiseasesGoldfishGram-Negative Bacterial InfectionsAnimalsFatty AcidsFemaleGastrointestinal TractMetabolomeMetabolomicsMultiomicsTranscriptomeFatty AcidsGene expressionsHybrid fishImmune responseMetabolic features

Identifiers

PMID41663608

DOI10.1007/s10126-026-10577-7

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.