Evidence map›Paper›PMID 41663457›Full record

ArticleScientific reports2026

Gait dysfunction as an early marker of phenoconversion in REM sleep behavior disorder.

Wiebke Hermann, Aleyna Sankutlu, Lydia Nabers, Tony Sehr, Katrin Trentzsch, Markus Donix, Heinz Reichmann, Moritz D Brandt, Alexander Storch, Tjalf Ziemssen

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wiebke HermannDepartment of Neurology, University Medical Center Rostock, University of Rostock, Schillingallee 35, 18147, Rostock, Germany. wiebke.hermann@med.uni-rostock.de.
Aleyna SankutluDepartment of Neurology, University Medical Center Rostock, University of Rostock, Schillingallee 35, 18147, Rostock, Germany.
Lydia NabersDepartment of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Tony SehrDepartment of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Katrin TrentzschDepartment of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Markus DonixDepartment of Psychiatry, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Heinz ReichmannDepartment of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Moritz D BrandtDepartment of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Alexander StorchDepartment of Neurology, University Medical Center Rostock, University of Rostock, Schillingallee 35, 18147, Rostock, Germany.
Tjalf ZiemssenDepartment of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical isolated REM Sleep Behavior Disorder (iRBD) is a prodromal stage of α-synucleinopathies such as Parkinson's disease (PD). Longitudinal changes of gait as a marker of phenoconversion in iRBD have not been systematically evaluated yet. Therefore, twenty-one iRBD patients, nineteen matched healthy controls and fourteen PD patients (H&Y stage I - III) were assessed at baseline using a pressure-sensor walkway (GAITRite). While normalized gait velocity and walking endurance were significantly decreased in iRBD patients compared to controls, gait rhythm parameters such as single support further discriminated PD from iRBD and controls. IRBD patients at imminent risk of phenoconversion within the next 3.7 ± 0.6 years were distinguishable from non-converters by gait rhythm parameters such as single support. Since gait evaluation of our iRBD cohort showed promising results in predicting imminent phenoconversion, future multicenter trials should include gait analysis as an objective assessment of motor function to confirm our results.

Indexed as

GaitParkinson DiseaseREM Sleep Behavior DisorderAgedBiomarkersCase-Control StudiesDisease ProgressionFemaleHumansMaleMiddle AgedBiomarkersGait dysfunctionParkinson’s diseaseProgressionREM sleep behaviour disorderΑ-synucleinopathies

Identifiers

PMID41663457
PMCPMC12891670

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.