ArticleNature communications2026
Recombinant zoster vaccine is associated with a reduced risk of dementia.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Effectiveness of the Recombinant Zoster Vaccine Against Herpes Zoster, Herpes Zoster Ophthalmicus, Postherpetic Neuralgia and Dementia: A Systematic Review and Meta-Analysis.Reviews in medical virology · 2026Pooled it
- Neuro- and cardioprotective benefits of recombinant herpes zoster vaccination.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- The skin as a sentinel organ for neurodegeneration: An underrecognized target for dementia prevention.Intractable & rare diseases research · 2026Review
- Article
- Viral infection states, immune control, and adult cognition: evidence across latency, persistence, and post-acute responses.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccines to prevent herpes zoster have been associated with reduced dementia risk. We conducted a retrospective matched cohort study of Kaiser Permanente Southern California members aged ≥65 years who received two doses of RZV 4 weeks-6 months apart between 01 April 2018 and 31 December 2020, with no dementia diagnoses or dementia medications prior to or within 6 months of their second RZV dose. Cox regression with inverse probability of treatment weighting was used to estimate adjusted hazard ratios (aHRs). The study included 65,800 RZV-vaccinated individuals and 263,200 unvaccinated matches. Vaccination with two doses of RZV was associated with a 51% lower risk of dementia (aHR: 0.49 [95% confidence interval (CI): 0.46-0.51]); aHRs were comparable across age, and racial and ethnic groups, but the risk reduction was stronger in females compared to males. In an evaluation of potential healthy vaccinee bias, the aHR of dementia for RZV compared to Tdap was 0.73 (95% CI: 0.67-0.79). Vaccination with two doses of RZV is associated with a statistically significant reduction in the risk of dementia in adults aged ≥65 years. After accounting for healthy vaccinee bias, RZV vaccination remains associated with a statistically significant lower risk of dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.