Evidence map›Paper›PMID 41663361›Full record

ArticleNature communications2026

Rapid dissemination of Staphylococcus aureus in the neonatal intensive care unit is associated with invasive infection.

Qianxuan She, Lakshmi Srinivasan, Erin Theiller, Bianca E Galis, T'Nia Napper, Andries Feder, Alex Arvanitis, Steven M Jones, Ericka Hayes, Karen M Puopolo and 10 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. IncreasedbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Qianxuan She *Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lakshmi Srinivasan *Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Erin TheillerCenter for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Bianca E GalisCenter for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
T'Nia NapperCenter for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Andries FederDivision of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Alex ArvanitisDivision of Pediatric Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Steven M JonesCenter for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ericka HayesDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-3679-9881
Karen M PuopoloDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Robert N BaldassanoDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael Z DavidDivision of Infectious Disease, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1926-7800
Susan E CoffinDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kathleen A GibbsDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Robert F PotterCenter for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kenneth P SmithDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rebecca M HarrisDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Joseph P ZackularCenter for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. joseph.zackular@pennmedicine.upenn.edu.ORCID 0000-0002-3228-3055
Ahmed M MoustafaDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. moustafaam@chop.edu.ORCID 0000-0002-9949-6936
Paul J PlanetDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. planetp@chop.edu.ORCID 0000-0003-0543-0539

Funding

High Resolution, Whole Genome Tracking of Pathogen Transmission and Infection in the Neonatal ICU (NICU)R01AI185544 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI Lakshmi Srinivasan · 2025 to 2026
$1.8M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) R01AI185544NIAID NIH HHS R01 AI185544
6 · The paper itself

Abstract

Staphylococcus aureus is a leading cause of severe infections in neonatal intensive care units (NICUs). We present results of precision surveillance of S. aureus carriage and invasive infection in a cohort study of high-risk infants in the NICU with the goal of identifying novel strategies for prevention and control. Using whole genome sequence guided epidemiology over a 3-year timeframe, we identify spatial and temporal links for transmission between babies, suggesting shared spaces, caregivers, and physical proximity as major risks for transmission in the NICU. Moreover, environmental surveillance reveals potential environmental reservoirs of S. aureus. Remarkably, specific clusters of S. aureus strains that are associated with invasive infection are also detected in more infants over time during routine surveillance, suggesting a strong link between the rate of dissemination and disease in this vulnerable population. Overall, our findings demonstrate a strong association amongst colonization, transmission, persistence, and the development of invasive infections, underscoring the importance of targeted measures to prevent S. aureus infections in the NICU setting.

Indexed as

Cross InfectionIntensive Care Units, NeonatalStaphylococcal InfectionsStaphylococcus aureusCarrier StateFemaleHumansInfant, NewbornMaleWhole Genome Sequencing

Identifiers

PMID41663361
PMCPMC13000299

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.