ArticleMolecular plant pathology2026
CtTLP13 Located in Extracellular Vesicles Enhances the Resistance of Safflower (Carthamus tinctorius) to Botrytis cinerea.
Article in Molecular plant pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Extracellular vesicles released by in vitro plant cell cultures: emerging systems for vesicle-mediated communication and biomedical translation.Plant cell reports · 2026Review
- Comparative Analysis of Extracellular Vesicle-Like Particles From Different ProcessingFood science & nutrition · 2026Article
- Localization and Functional Analysis of CtLTP8, an Extracellular Vesicle Protein That Enhances Resistance toPlants (Basel, Switzerland) · 2026Article
- CtTLP13 Located in Extracellular Vesicles Enhances the Resistance of Safflower (Carthamus tinctorius) to Botrytis cinerea.Molecular plant pathology · 2026Article
- CtChi19: a valuable gene for improving resistance to Botrytis cinerea and Alternaria alternata in Carthamus tinctorius.Frontiers in plant science · 2026Article
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Authors and funding
17 authors.
Funding
Abstract
Safflower (Carthamus tinctorius), a versatile economic crop of the Asteraceae family used for both medicinal and oil purposes, is widely cultivated worldwide. During its growth period, particularly during the harvesting phase, safflower is susceptible to fungal infections, leading to reduced product quality and yield. Currently, there is a lack of research on candidate genes associated with safflower disease resistance, which hinders the breeding of disease-resistant varieties of safflower. The disease severity index of 499 safflower germplasm lines during the flowering period was analysed through genome-wide association studies (GWAS), and a highly correlated TLP (thaumatin-like proteins) family disease resistance candidate gene, CtTLP13, was identified. Subsequently, transcriptomic and proteomic analyses were conducted to characterise the molecular features of safflower under fungal infection, and it was confirmed that CtTLP13 can respond to the biotic stress when safflower is infected by Botrytis cinerea. CtTLP13 overexpression in Arabidopsis and safflower enhanced safflower disease resistance; in vitro experiments confirmed its inhibition of B. cinerea growth and spore germination. We isolated safflower extracellular vesicles (EVs), verified CtTLP13 localisation within them and showed that CtTLP13-carrying safflower EVs are taken up by B. cinerea and inhibit the fungal growth. Overall, this study identified a valuable disease resistance gene (CtTLP13) in safflower. We also investigated the role of safflower EVs in disease resistance, and the results showed that safflower EVs exhibit anti-B. cinerea activity.
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