ArticleBrain tumor research and treatment2026
The Dual Impact of Glioma Resection on Survival and Health-Related Quality of Life: Resect More, Live Better.
Article in Brain tumor research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Comparative Evaluation of ChatGPT-5.2, Claude Sonnet 4.5, and DeepSeek-V3.2 for Rosacea-Related Information: Accuracy, Reliability, Readability, and Reference Hallucinations.Diagnostics (Basel, Switzerland) · 2026Article
- GABA-Producing Capabilities ofJournal of microbiology and biotechnology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundHealth-related quality of life (HR-QoL) is a critical consideration in glioma surgery, alongside improving patient survival. Current evidence highlights maximal surgical resection as a key independent prognostic factor for enhancing HR-QoL and survivability. This study aimed to compare the impact on HR-QoL and survival rates in glioma patients before and after surgery with varying degrees of tumor resection (<10%, 10%-90%, >90%) and residual tumor volumes (≤2 cm³, >2 cm³).
methodsThis single-institution prospective study analyzed 117 patients with newly diagnosed gliomas (2009-2015). HR-QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) (global quality of life status [GQLS], physical, emotional, role, cognitive, and social function, as well as insomnia and fatigue). We compared survival rates and HR-QoL outcomes based on extent of resection and residual tumor volume. Clinically meaningful thresholds and statistical significance were used to evaluate HR-QoL changes.
resultsIn grade 4 gliomas, resections >90% and residual tumor volumes ≤2 cm³ significantly improved median survival compared to lesser resections. For HR-QoL, resections >90% led to clinically and statistically significant improvements in GQLS, emotional, role, and cognitive function, as well as insomnia. Residual volumes ≤2 cm³ significantly enhanced emotional and role function, with statistical improvements in GQLS, cognitive function, social function, insomnia, and fatigue. Lower resection rates and higher residual volumes resulted in significant HR-QoL declines. When stratified by tumor grade, high- and low-grade gliomas showed clinically significant improvements in different HR-QoL domains.
conclusionResections greater than 90% and residual volumes ≤2 cm³ significantly improve HR-QoL and overall survival. Conversely, partial resections and larger residual tumor volumes are associated with worse HR-QoL outcomes.
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Registered trials
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