Evidence map›Paper›PMID 41663151›Full record

Observational studyOpen heart2026

Association of epicardial adipose tissue with markers of cardiac remodelling and clinical outcomes in asymptomatic aortic stenosis.

Sarah L Ayton, Saadia Aslam, Abhishek Dattani, Jian L Yeo, Gaurav S Gulsin, Piotr J Slomka, Damini Dey, Gerry P McCann, Anvesha Singh

2 registry-linked trialsAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Open heart, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03132129 recruitingnot on this map

Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes Mellitus

TypeobservationalSponsorUniversity of LeicesterRan2017 to 2029Enrolled593ConditionsDiabetes Mellitus, Type 2, Diabetic CardiomyopathiesArmsCardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography, Computed tomography coronary artery calcium scoring, Cardiopulmonary exercise testing, Manganese-enhanced magnetic resonance imaging (MEMRI)
NCT03518645 nacompletednot on this map

Optimal Lesion Preparation With Non-compliant Balloons for the Implantation of Bioresorbable Vascular Scaffolds (BVS) -OPRENBIS Study

TypeinterventionalSponsorKCRIRan2015 to 2018Enrolled43ConditionsCoronary Artery Disease, Angina, Unstable, Angina, StableArmsOPN strategy, standard strategy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Excess Epicardial Fat and Myocardial Remodeling After Mitral Valve Surgery.Journal of cardiovascular development and disease · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah L AytonDepartment of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and Leicester National Institute for Health and Care Research Biomedical Research Centre, University of Leicester, Leicester, UK sa768@leicester.ac.uk.ORCID 0000-0001-9896-1894
Saadia AslamDepartment of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and Leicester National Institute for Health and Care Research Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID 0000-0002-8370-186X
Abhishek DattaniDepartment of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and Leicester National Institute for Health and Care Research Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID 0000-0001-7405-6056
Jian L YeoDepartment of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and Leicester National Institute for Health and Care Research Biomedical Research Centre, University of Leicester, Leicester, UK.
Gaurav S GulsinDepartment of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and Leicester National Institute for Health and Care Research Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID 0000-0002-1740-9270
Piotr J SlomkaBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-6110-938X
Damini DeyBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0003-2236-6970
Gerry P McCannDepartment of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and Leicester National Institute for Health and Care Research Biomedical Research Centre, University of Leicester, Leicester, UK.ORCID 0000-0002-5542-8448
Anvesha SinghDepartment of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and Leicester National Institute for Health and Care Research Biomedical Research Centre, University of Leicester, Leicester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have suggested an adverse role of epicardial adipose tissue (EAT) in aortic stenosis (AS), potentially mediated by direct effects on the myocardium. This study aimed to assess whether EAT volume and density are associated with cardiac remodelling and clinical outcomes in a well-phenotyped cohort of patients with initially asymptomatic AS.

methodsIn this post hoc exploratory analysis of a multicentre, prospective longitudinal study, asymptomatic patients with moderate-to-severe AS (n=136; age 68.6 (60.1, 75.3) years, 27% female) and control participants (n=39; age 59.0 (54.0, 67.0) years, 38% female) underwent echocardiography, cardiac CT and MRI. EAT volume and mean CT attenuation were measured from non-contrast cardiac CT using an automated deep learning software. The primary outcome was symptoms necessitating valve replacement, cardiovascular death or major adverse cardiac event.

resultsParticipants with AS had significantly higher indexed EAT volumes (56.5 vs 38.8 cm

conclusionIndexed EAT volume was higher in patients with AS, but not associated with MRI markers of cardiac remodelling. A higher indexed EAT volume was independently associated with a lower occurrence of symptoms and cardiovascular events. Further studies are needed to corroborate these findings and whether EAT has a potentially protective role in symptom progression in AS. TRIAL REGISTRATION NUMBERS: NCT03518645, NCT03132129.

Indexed as

Aortic Valve StenosisEpicardial Adipose TissueVentricular Function, LeftVentricular RemodelingAgedAsymptomatic DiseasesEchocardiographyFemaleHumansLongitudinal StudiesMagnetic Resonance Imaging, CineMaleMultidetector Computed TomographyProspective StudiesSeverity of Illness Indexaortic valve stenosismagnetic resonance imagingmultidetector computed tomographyobesity

Identifiers

PMID41663151
PMCPMC12887484

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.