Trial reportBMJ open gastroenterology2026
Assessment of transmural treatment response in known Crohn's disease: a prospective blinded study of the intermodality agreement between intestinal ultrasound and magnetic resonance enterography.
Trial report in BMJ open gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03435016 (A Comparative Study of Magnetic Resonance Imaging, Ultrasound and Capsule Endoscopy of the Small and Large Intestine for Assessing Treatment Response in Known Crohn's Disease), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Comparative Study of Magnetic Resonance Imaging, Ultrasound and Capsule Endoscopy of the Small and Large Intestine for Assessing Treatment Response in Known Crohn's Disease
Who cites it
2 citing papers in PubMed.
- Intestinal Ultrasound-Guided Precision Medicine in Inflammatory Bowel Diseases: A Narrative Review.Journal of personalized medicine · 2026Review
- Mechanosensitive ion channels in intestinal homeostasis and disease.eGastroenterology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIntestinal ultrasound (IUS) and magnetic resonance enterography (MRE) are state-of-the-art modalities recommended for monitoring Crohn's disease (CD) activity and treatment response. This study aimed to examine the intermodality agreement for determining transmural response to medical treatment.
methodsIUS and MRE performed in a prospective, blinded, multicentre study were included in the analysis. Patients with endoscopically active CD completed IUS and MRE before and after medical treatment. Observers were blind to the result of the other modality. Findings and disease classification at baseline, as well as the intermodality agreement for transmural treatment response, were determined.
results35 patients entered the analysis. IUS and MRE detected 59 (24.1%) and 42 (17.1%) segments with active CD at baseline, respectively (p=0.001). Disease location and behaviour were determined with a moderate intermodality agreement (κ=0.48 and κ=0.43, p<0.01). Global IUS and MRE activity scores decreased after medical treatment (p<0.05), and repeated measurement correlations were weak to moderate. The intermodality agreement for transmural treatment response was fair to moderate: IUS versus Magnetic Resonance Index of Activity κ=0.43 (95% CI 0.13 to 0.73, p=0.006) and IUS versus Clermont score κ=0.31 (95% CI 0.01 to 0.60, p=0.026). Normalisation of bowel wall thickness occurred in 12 (34.3%) patients with MRE and 11 (31.4%) patients with IUS. The intermodality agreement was moderate (κ=0.42, 95% CI 0.10 to 0.74, p=0.007).
conclusionTransmural response and healing are determined with considerable variability. Maintaining consistency in imaging modality between assessments is essential to ensure an accurate interpretation. TRIAL REGISTRATION NUMBER: NCT03435016.
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