ArticleThoracic cancer2026
PD-L1 Expression and Histopathological Features in EGFR-Mutated Non-Small Cell Lung Cancer: Implications for Immune Checkpoint Inhibitors After EGFR-Tyrosine Kinase Inhibitors Resistance.
Article in Thoracic cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Biomarker exploration for immunotherapy plus chemotherapy following resistance to third-generation EGFR-TKIs in lung adenocarcinoma.BMC cancer · 2026Article
- PD-L1 Expression and Histopathological Features in EGFR-Mutated Non-Small Cell Lung Cancer: Implications for Immune Checkpoint Inhibitors After EGFR-Tyrosine Kinase Inhibitors Resistance.Thoracic cancer · 2026Article
- Methylation of DPP9 regulates immune surveillance in non-small cell lung cancer by promoting macrophage ferroptosis via WWP2 ubiquitination.American journal of cancer research · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC) responds well to EGFR tyrosine kinase inhibitors (EGFR-TKIs), yet optimal therapy after resistance remains uncertain. Although immune checkpoint inhibitors (ICIs) show limited overall efficacy, heterogeneity in response by programmed cell death ligand 1 (PD-L1) expression exists.
methodsWe retrospectively evaluated 90 patients with advanced/recurrent EGFRm NSCLC treated with first-line EGFR-TKIs (October 2018-October 2023). Clinicopathological and radiologic features were compared by PD-L1 tumor proportion score (< 50% vs. ≥ 50%). The primary analysis evaluated overall survival from first progression (post-progression OS/PPS) using a time-varying Cox model with start-stop intervals, modeling ICI as a time-dependent exposure ICI(t) and testing the ICI(t) × PD-L1 interaction.
resultsThe PD-L1 ≥ 50% group (n = 26) more often had solid histology (62% vs. 8%), solid nodules on computed tomography (96% vs. 52%), and larger tumors (median 42.0 vs. 27.5 mm). Among 68 patients evaluable from t
conclusionsHigh PD-L1 expression in EGFRm NSCLC is associated with more aggressive morphologic features and modifies the association between post-progression ICI and survival. These findings support PD-L1-informed selection after EGFR-TKI failure, while prospective confirmation is needed.
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