Evidence map›Paper›PMID 41663073›Full record

ArticleJournal of medicinal chemistry2026

Discovery of EGT710, an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor.

Julien P N Papillon, Jun Yuan, Matthew J Hesse, Lei Zhang, Richard I Robinson, Nathaniel F Ware, Viktor Hornak, Rajeshri G Karki, Tom Kirrane, Keira Garland and 25 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Julien P N PapillonGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-8952-5289
Jun YuanGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Matthew J HesseGlobal Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States.ORCID 0000-0002-4759-5086
Lei ZhangGlobal Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States.ORCID 0009-0002-3067-1369
Richard I RobinsonGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-7209-3424
Nathaniel F WareGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Viktor HornakGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-2344-9586
Rajeshri G KarkiGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.ORCID 0000-0003-2210-5789
Tom KirraneGlobal Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States.
Keira GarlandGlobal Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States.
Sajan JosephGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Stephanie A MoquinDiscovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States.ORCID 0000-0002-8696-4315
Suresh B LakshminarayanaPharmaceutical Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States.
Laura TandeskeDiscovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States.
Dustin DovalaDiscovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States.ORCID 0000-0002-2278-5027
Mark KnappDiscovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States.
Elizabeth OrnelasDiscovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States.
Daniel FullerDiscovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Pei-I HoDiscovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Xuping XieUniversity of Texas Medical Branch, Galveston, Texas 77555, United States.
Katarina VulicTechnical Research & Development, Development, Novartis, Cambridge, Massachusetts 02139, United States.
Suzanne M SkolnikGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Jinhai GaoGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-1687-2941
Mark ZambrowskiGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Meike SpiessGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
José S DucaGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Scott A BusbyDiscovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Markus SchirleDiscovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.ORCID 0000-0003-4933-2623
Michael RobinsonGlobal Health, Biomedical Research, Novartis, Emeryville, California 94608, United States.
Pei-Yong ShiUniversity of Texas Medical Branch, Galveston, Texas 77555, United States.
Heinz E MoserGlobal Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Christopher SarkoGlobal Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States.
James E BradnerBiomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Thierry T DiaganaDiscovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States.
John A TallaricoDiscovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.

Funding

Bill & Melinda Gates Foundation INV-033028
6 · The paper itself

Abstract

The coronavirus main protease (3CL

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesProtease InhibitorsSARS-CoV-2Administration, OralAnimalsCrystallography, X-RayDrug DesignDrug DiscoveryHumansStructure-Activity Relationship3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesProtease Inhibitors

Identifiers

PMID41663073
PMCPMC12951577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.