Evidence map›Paper›PMID 41662713›Full record

GuidelineAnnals of internal medicine2026

Outpatient Treatment of Confirmed COVID-19 in Symptomatic Adults: Living, Rapid Practice Points From the American College of Physicians (Version 3).

Amir Qaseem, Adam J Obley, Jennifer Yost, George M Abraham, Rebecca A Andrews, Janet A Jokela, Matthew C Miller, Linda L Humphrey, Population Health and Medical Science Committee of the American College of Physicians, Ray Haeme and 9 more

Abstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Annals of internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Amir QaseemAmerican College of Physicians, Philadelphia, Pennsylvania (A.Q.).ORCID 0000-0001-6866-7985
Adam J ObleyStritch School of Medicine, Loyola University Chicago, Maywood, Illinois (A.J.O.).
Jennifer YostAmerican College of Physicians, Philadelphia, and Villanova University, Villanova, Pennsylvania (J.Y.).
George M AbrahamUniversity of Massachusetts Medical School and Saint Vincent Hospital, Worcester, Massachusetts (G.M.A.).ORCID 0000-0003-4296-8362
Rebecca A AndrewsUniversity of Connecticut School of Medicine, Farmington, Connecticut (R.A.A.).ORCID 0000-0002-2658-226X
Janet A JokelaCarle Illinois College of Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois (J.A.J.).ORCID 0000-0003-4324-4809
Matthew C MillerPenn Medicine, Gladwyne, Pennsylvania (M.C.M.).ORCID 0000-0001-7267-4897
Linda L HumphreyOregon Health & Science University, Portland, Oregon (L.L.H.).
Population Health and Medical Science Committee of the American College of Physicians
Ray Haeme
Alysa Krain
Thejaswi Poonacha
Sameer D Saini
Timothy J Wilt
Kate Carroll
Itziar Etxeandia-Ikobaltzeta
Curtis S Harrod
Tatyana Shamliyan
Chelsea Vigna

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

descriptionThe American College of Physicians (ACP) maintains living, rapid practice points on antiviral treatment in the outpatient setting for COVID-19.

methodsThe Population Health and Medical Science Committee (PHMSC) developed this version 3 based on evidence from a focused update of a living, rapid review conducted by the ACP Center for Evidence Reviews at Cochrane Austria. This version addresses the SARS-CoV-2 Omicron variant and reaffirms previous practice points on the use of antiviral treatments of confirmed COVID-19 in unvaccinated or vaccinated and symptomatic patients in the outpatient setting. PRACTICE POINT 1: PRACTICE POINT 2: PRACTICE POINT 3: PRACTICE POINT 4: RETIREMENT FROM LIVING STATUS: The PHMSC is retiring this topic from living status considering that this update and previous surveillance have not yielded important changes to the practice points.

Indexed as

Ambulatory CareAntiviral AgentsCOVID-19 Drug TreatmentAdultCOVID-19HumansPandemicsSARS-CoV-2United StatesAntiviral Agents

Identifiers

PMID41662713

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.