ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Post-Translational Modifications in Animal Circadian Clocks.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- [Interactions among circadian rhythm, obesity, and inflammation and their regulation by exercise].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- Nutritional adaptation to circadian misalignment: implications for musculoskeletal health in modern lifestyles.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The circadian clock is a fundamental biological system that synchronizes behavioral and physiological processes such as metabolism and immunity with the 24 h day-night cycle. Disruption of circadian rhythms, often caused by modern lifestyle factors like shift work and jet lag, is closely associated with metabolic and mental disorders. In both mammals and Drosophila, the molecular oscillator consists of conserved transcriptional-translational feedback loops (TTFLs) involving positive and negative regulatory elements that generate rhythmic gene expression. Post-translational modifications (PTMs) of clock proteins play crucial roles in modulating the circadian period length, robustness, and responsiveness to environmental cues. Importantly, casein kinase 1 family-dependent phosphorylation on both positive and negative elements in animal clocks highlights the evolutionary convergence of circadian timekeeping across species. This review focuses on PTMs and related mechanisms in circadian timekeeping and their roles in adapting to environmental and physiological signals in animals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.