Evidence map›Paper›PMID 41662525›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Antagonism of RNA silencing in the yellow fever mosquito,

Adarsh K Gupta, Michael R Wiley, Kevin M Myles

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Antagonism of RNA silencing in the yellow fever mosquito,Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adarsh K GuptaDepartment of Entomology and AgriLife Research, Texas A&M University, College Station, TX 77843.ORCID 0000-0002-5038-2858
Michael R WileyDepartment of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, College of Medicine, Omaha, NE 68198.
Kevin M MylesDepartment of Entomology and AgriLife Research, Texas A&M University, College Station, TX 77843.ORCID 0000-0002-9820-2502

Funding

Aedes antiviral RNAi pathwayR01AI141532 · NIAID · JOHNS HOPKINS UNIVERSITY · PI George Dimopoulos, KEVIN M MYLES · 2019 to 2026
$4.6M
Modulation of arboviruses in mosquitoesR01AI077726 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI MYLES, KEVIN M · 2008 to 2012
$1.9M
Hierarchical antiviral immunity in disease vector mosquitoesR01AI119081 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI MYLES, KEVIN M · 2015 to 2019
$1.9M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI077726HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI119081HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI141532NIAID NIH HHS R01 AI077726NIAID NIH HHS R01 AI119081NIAID NIH HHS R01 AI141532
6 · The paper itself

Abstract

Alphaviruses establish persistent infections in mosquito vectors despite robust antiviral RNA interference (RNAi) pathways, suggesting that they employ mechanisms to counteract host immunity. We demonstrate that the nsP2 protein of Sindbis virus (SINV), the prototype alphavirus, functions as a viral suppressor of RNA silencing in

Indexed as

AedesRNA InterferenceSindbis VirusViral Nonstructural ProteinsAnimalsMosquito VectorsMutationRNA, Small InterferingRNA, ViralVirus ReplicationYellow FeverRNA, Small InterferingRNA, ViralViral Nonstructural ProteinsAlphavirusRNAiRNA silencingSindbisVSR

Identifiers

PMID41662525
PMCPMC12913014

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.