In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Leonard F Lebender *Institute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, Bonn 53127, Germany.ORCID 0000-0001-9621-5214 Alexander Seidinger *Department of Systems Physiology, Medical Faculty, Institute of Physiology, Ruhr University Bochum, Bochum 44801, Germany.
Michaela MattheyDepartment of Systems Physiology, Medical Faculty, Institute of Physiology, Ruhr University Bochum, Bochum 44801, Germany.ORCID 0000-0002-1841-2906 Birte DyckDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, Knappschaft Kliniken University Hospital Bochum, Ruhr University Bochum, Bochum 44892, Germany.ORCID 0000-0002-1013-0015 Christian SchlammAgnes Wittenborg Institute for Translational Cardiovascular Research, Herz- und Diabeteszentrum North Rhine-Westphalia, University Hospital of the Ruhr University Bochum, Bad Oeynhausen 32545, Germany.ORCID 0009-0007-5260-1149 Abdullah KaddouraDepartment of Systems Physiology, Medical Faculty, Institute of Physiology, Ruhr University Bochum, Bochum 44801, Germany.
Maximilian HausherrMedical Proteome Analysis, Center for Protein Diagnostics, Ruhr University Bochum, Bochum 44801, Germany.
Britta EggersMedical Proteome Analysis, Center for Protein Diagnostics, Ruhr University Bochum, Bochum 44801, Germany.ORCID 0000-0002-6553-4631 Katrin MarcusMedical Proteome Analysis, Center for Protein Diagnostics, Ruhr University Bochum, Bochum 44801, Germany.ORCID 0000-0002-3313-8845 Evi KostenisMolecular-, Cellular-, and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of Bonn, Bonn 53115, Germany.ORCID 0000-0001-8284-5514 Volkmar GieselmannInstitute of Biochemistry and Molecular Biology, Medical Faculty, University of Bonn, Bonn 53115, Germany.
Michael AdamzikDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, Knappschaft Kliniken University Hospital Bochum, Ruhr University Bochum, Bochum 44892, Germany.
Anna KlinkeAgnes Wittenborg Institute for Translational Cardiovascular Research, Herz- und Diabeteszentrum North Rhine-Westphalia, University Hospital of the Ruhr University Bochum, Bad Oeynhausen 32545, Germany.
Björn KoosDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, Knappschaft Kliniken University Hospital Bochum, Ruhr University Bochum, Bochum 44892, Germany.
Bernd K FleischmannInstitute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, Bonn 53127, Germany.ORCID 0000-0002-9202-8363 Daniela WenzelInstitute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, Bonn 53127, Germany.ORCID 0000-0003-1100-6363 Funding
Deutsche Forschungsgemeinschaft (DFG) 214362475Georg E and Marianne Kosing Foundation no number
6 · The paper itselfAbstract
Pulmonary arterial hypertension (PAH) is a serious disorder, in which increased vascular tone is one of the critical hallmarks. Since beta arrestins (bArrs) have been shown to regulate smooth muscle tone in the airways, we investigated the function of bArr1 in the pulmonary vasculature. Here, we report that bArr1 is essential for maintaining normal pulmonary arterial tone. Specifically, pulmonary arteries from bArr1-/- mice exhibited reduced NO-dependent vasorelaxation due to impaired soluble guanylyl cyclase (sGC) activity, which was restored by the heme-independent sGC activator BAY58-2667. We identified bArr1 as a binding partner of sGC and the sGC heme reductase cytochrome b5 reductase (Cyb5r3), indicating that bArr1 is vital for sensitizing sGC to NO. Finally, mice with either ubiquitous or smooth muscle-specific bArr1 deficiency developed pulmonary hypertension (PH). These findings highlight the important role of bArr1 in regulating pulmonary vascular tone and propose it as a potential therapeutic target for the treatment of PH.
Indexed as
Arrestinsbeta-Arrestin 1Hypertension, PulmonaryPulmonary ArteryAnimalsBenzoatesbeta-ArrestinsMiceMice, KnockoutMuscle, Smooth, VascularNitric OxideSoluble Guanylyl CyclaseVasodilationArrb1 protein, mouseArrestinsBAY 58-2667Benzoatesbeta-Arrestin 1beta-ArrestinsNitric OxideSoluble Guanylyl Cyclasebeta arrestinpulmonary hypertensionsoluble guanylyl cyclase
Identifiers
PMID41662523
PMCPMC12913011
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