Trial reportPloS one2026
Protocol of a multi-centre randomized controlled trial to compare pericapsular nerve group block, fascia-iliaca compartment block and femoral nerve block for pain management in patients with a hip fracture in the emergency department (CPFF-ED).
Trial report in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients presenting in the emergency department (ED) with a hip fracture are often in significant pain. Opioids are frequently prescribed as part of standardized pain protocols, but are associated with many adverse events, especially in the elderly. Regional anaesthesia with a femoral nerve block (FNB), Fascia Iliaca compartment block (FICB) or Pericapsular nerve block (PENG) may provide a reasonable alternative to these patients. We designed a prospective multicentre study to compare the efficacy and safety of these blocks in the ED setting, which has been registered in the Centrale Commissie Mensgebonden Onderzoek (CCMO) Research Portal (NL-OMON57433). METHODS AND ANALYSIS: A multicentre Randomized Controlled Trial (RCT), conducted in the ED of 5 hospitals in the Netherlands. A total of 254 adult patients (18+) presenting to the ED with a neck of femur or pertrochanteric femur fracture will be randomised to receive FNB, FICB or PENG in the ED after informed consent has been obtained. Patients will be followed for 12 hours after block placement in the ED. The primary (patient reported) outcome measure is overall patient wellbeing 6-8 hours after block administration (or until operation, whichever comes first) as scored by the validated Quality of Recovery (QoR-15) questionnaire. Secondary outcome measures will be pre-operative pain scores, the cumulative dose of analgesics used during the first 12 hours after block placement or until operation, and complication rates for each of the blocks. EXPECTED
resultsThis randomized controlled trial with a superiority design will allow conclusions on which regional nerve block is most effective in improving pre-operative wellbeing in patients with a neck of femur or pertrochanteric fracture. The choice to use a patient reported outcome measure to evaluate block efficacy maximizes clinical relevance. And by allowing the choice of local anaesthetic to the participating hospital (with a 1:1:1 randomization for each participating centre) clinical applicability of our findings is maximized.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.