Evidence map›Paper›PMID 41661589›Full record

ArticleNeuropsychology2026

Measurement differences in the Harmonized Cognitive Assessment Protocol across ethnicity and language in the United States.

Emily M Briceño, Lewis B Morgenstern, Zachary J Kunicki, Deborah A Levine, Roshanak Mehdipanah, Nelda Garcia, Wen Chang, Xavier F Gonzales, Bruno Giordani, Steven G Heeringa and 3 more

Abstract read
In one paragraph

Article in Neuropsychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emily M BriceñoDepartment of Physical Medicine and Rehabilitation, University of Michigan Medical School.ORCID 0000-0002-9360-8917
Lewis B MorgensternDepartment of Neurology, University of Michigan Medical School.
Zachary J KunickiDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University.
Deborah A LevineDepartment of Neurology, University of Michigan Medical School.
Roshanak MehdipanahDepartment of Health Behavior and Health Equity, School of Public Health, University of Michigan.
Nelda GarciaDepartment of Neurology, University of Michigan Medical School.
Wen ChangInstitute for Social Research, University of Michigan.
Xavier F GonzalesDepartment of Life Sciences, Texas A&M University-Corpus Christi.
Bruno GiordaniDepartment of Psychiatry, University of Michigan Medical School.
Steven G HeeringaInstitute for Social Research, University of Michigan.
Darin B ZahuranecDepartment of Neurology, University of Michigan Medical School.
Kenneth M LangaDepartment of Internal Medicine, University of Michigan Medical School.ORCID 0000-0002-2798-1836
Richard N JonesDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2M
Health and Retirement Study: Harmonized Cognitive Assessment Protocol (HCAP)U01AG058499 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LANGA, KENNETH M · 2018 to 2023
$8.3M
Cognitive impairment in Mexican Americans: a population-based studyR01NS100687 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORGENSTERN, LEWIS B · 2017 to 2021
$7.4M
Critical Decision Making in Alzheimer's Disease and Related Dementias in Mexican AmericansR01AG069148 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORGENSTERN, LEWIS B, ZAHURANEC, DARIN B · 2020 to 2024
$3.5M
Measurement of cognition and functional decline in Latinx older adults for detection of Alzheimer’s Disease and Related Dementias: A mixed-methods approachK23AG080035 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Emily Marie Briceno · 2023 to 2026
$767k
Alzheimer's AssociationNIA NIH HHSNIA NIH HHS K23 AG080035NIA NIH HHS P30 AG024824NIA NIH HHS R01 AG069148NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG058499NIH HHSNINDS NIH HHS R01 NS100687
6 · The paper itself

Abstract

objectivesThe Harmonized Cognitive Assessment Protocol (HCAP) is a neuropsychological assessment for dementia that is used to derive national dementia prevalence estimates through a substudy of the Health and Retirement Study. We aimed to evaluate the degree of measurement invariance of the HCAP across Hispanic/Latino-a-e-x (H/L) and non-H/L white (NHW) older adults in the United Study.

methodWe combined HCAP data from two large cohort studies. We used multiple-group confirmatory factor analysis to evaluate measurement invariance across H/L adults assessed in English (

resultsWe observed measurement differences in the HCAP across H/L and NHW older adults for the memory, language, executive functioning, and orientation, but not visuospatial, domains. Effect sizes for measurement differences in HCAP items ranged from small to large. Not accounting for measurement differences led to meaningful underestimation of cognitive function ranging from 5% (language domain) to 82% (executive functioning domain) of H/L individuals assessed in English and 11% (memory domain) to 96% (executive functioning domain) of H/L individuals assessed in Spanish.

conclusionsThe interpretation of ethnic differences in cognitive function with the HCAP may be confounded with measurement differences. Measurement equivalence in cognitive assessment instruments across H/L and NHW populations cannot be assumed. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

Indexed as

CognitionDementiaHispanic or LatinoLanguageNeuropsychological TestsWhiteAgedAged, 80 and overExecutive FunctionFactor Analysis, StatisticalFemaleHumansMaleMemoryUnited States

Identifiers

PMID41661589
PMCPMC12888800

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.