Histological and Immunohistochemical Analysis of the Mouse Brain Following Traumatic Brain Injury: Identification of Therapeutic Targets and Establishment of Treatment Windows.

N N Ermakova, E S Pan, M A Zhukova, V Yu Pan, I L Zharkikh, V E Skurikhina, A M Dygai

Abstract read

In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

7 authors.

N N ErmakovaInstitute of General Pathology and Pathophysiology, Moscow, Russia.

E S PanInstitute of General Pathology and Pathophysiology, Moscow, Russia.

M A ZhukovaInstitute of General Pathology and Pathophysiology, Moscow, Russia. mashazyk@gmail.com.

V Yu PanInstitute of General Pathology and Pathophysiology, Moscow, Russia.

I L ZharkikhInstitute of General Pathology and Pathophysiology, Moscow, Russia.

V E SkurikhinaInstitute of General Pathology and Pathophysiology, Moscow, Russia.

A M DygaiInstitute of General Pathology and Pathophysiology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A histological and immunohistochemical analysis (IHC) of the motor cortex and subventricular zone (a neurogenic region) in the right cerebral hemisphere of ICR mice was performed following traumatic brain injury (TBI) induced at the bregma level. Hematoxylin-eosin and cresyl violet staining revealed that TBI causes significant damage to the motor cortex, including tissue edema, neuroinflammation, vascular congestion, cellular and tissue degeneration, disruption of the vascular network, astrolysis, and glial scar formation. Concurrently, the number of neurons in the motor cortex was reduced, while the number of glial cells increased. IHC analysis showed a decreased population of DCX

Indexed as

Brain Injuries, TraumaticMotor CortexAnimalsAntigens, NuclearAstrocytesBrainCell MovementDisease Models, AnimalDNA-Binding ProteinsDoublecortin ProteinGlial Fibrillary Acidic ProteinImmunohistochemistryLateral VentriclesMaleMiceMice, Inbred ICRAntigens, NuclearDcx protein, mouseDNA-Binding ProteinsDoublecortin ProteinGlial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseMicrotubule-Associated ProteinsNerve Tissue ProteinsNeuN protein, mouseNeuropeptidesmotor cortexneurogenesisneuroinflammationsubventricular zonetraumatic brain injury

Identifiers

PMID41661427

DOI10.3390/ijms25073788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.