ArticleBulletin of experimental biology and medicine2025
Impact of Immobilization Stress on the Redox System in Prenatally Stressed Rats.
Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The dynamics of protein oxidative modification, superoxide dismutase (SOD) activity, and reduced glutathione levels were studied in the control and prenatally-stressed male rats following immobilization stress. The control group consisted of intact males not exposed to prenatal stress. Prenatal stress was modeled by immobilizing pregnant rats for 1 h per day on gestational days 15-19. Male offspring (3-months-old) were subjected to a 20 min immobilization stress. In both groups, the specified parameters were assessed at baseline (no stress), immediately after stress, and after 1, 3, and 24 h of post-stress. Prenatal stress attenuated the reactivity of these redox indicators, whereas control animals exhibited pronounced pro- and antioxidant responses following immobilization. These findings suggest that prenatal stress impairs the adaptive capacity of the redox system in adult offspring.
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