Evidence map›Paper›PMID 41661380›Full record

ReviewVeterinary research communications2026

Research progress on NSP4 protein of porcine reproductive and respiratory syndrome virus.

Xiaolin Lan, Fang Liang, Gan Li, Yaqiong Ye, Feng Li, Chen Lv, Kexin Liu, Zhiyu Yang, Ruyu Sun, Keshan Zhang and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaolin LanGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China.
Fang LiangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China.
Gan LiGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China.
Yaqiong YeGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China.
Feng LiCenter of animal epidemic disease prevention control, Long zhouxian County, Chongzuo City, Guangxi Zhuang Autonomous Region, China.
Chen LvGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China.
Kexin LiuGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China.
Zhiyu YangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China.
Ruyu SunGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China.
Keshan ZhangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China.
Lin WangInstitute of Cancer Sciences, University of Glasgow, Glasgow, G12800, UK.
Huawei LiCollege of Veterinary Medicine, Henan University of Animal Husbandry and Economy, Zhengzhou, 450046, China.
Mengmeng ZhaoGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China. mengmengzhao2021@fosu.edu.cn.
Liangzong HuangGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Animal Science and Technology, Foshan University, Foshan Guangdong, 528225, China. huangliangzong@fosu.edu.cn.

Funding

Foshan University 2025 Graduate Excellence and Innovation Program FOSU2025ZYCX-M04Guangdong Basic and Applied Basic Research Foundation 2024A1515140152Guangdong Provincial Department of Education's distinctive innovation initiative 2023KTSCX128Key Research and Development Special Project of Henan Province 251111113600National Key Research and Development Program Projects 2023YFD1801302Research Start-up Project for High-level Talents of Foshan University CGZ07001Special Funds for Rural Revitalization Strategy of Guangdong Provincial Department of Agri-culture and Rural Affairs in 2024 2024CXTD15the National Natural Science Foundation of China 31902279
6 · The paper itself

Abstract

Porcine Reproductive and Respiratory Syndrome (PRRS), caused by the PRRS virus (PRRSV), is a prevalent swine pathogen that results in reproductive and respiratory issues. The non-structural protein 4 (NSP4) of PRRSV is a 3C-like serine enzyme with a vital triad (His39-Asp64-Ser118), which is crucial for cleaving viral polyproteins pp1a and pp1ab to yield operational non-structural proteins (NSP3-NSP12). In addition to its role in viral replication, NSP4 suppresses interferon production and triggers host cellular apoptosis, thereby facilitating immune evasion and disease progression. This review provides insights into the structure and function of NSP4, which provide perspectives for enhancing PRRS management strategies and formulating more potent vaccines.

Indexed as

Porcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusViral Nonstructural ProteinsAnimalsSwineVirus ReplicationViral Nonstructural ProteinsNSP4Porcine reproductive and respiratory syndrome virusResearch progress

Identifiers

PMID41661380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.