Evidence map›Paper›PMID 41661358›Full record

ArticleNeurochemical research2026

MARCH6 Confers Protection Against Endoplasmic Reticulum Autophagy in Gliomas by Destabilizing FAM134B.

Yeming Zhou, Rui Chen, Guokun Liu, Lu Zhang, Hongyan Zheng, Jinyu Zheng, Xiaohua Zuo, Peng Xie

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yeming Zhou *Department of Emergency, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Rui Chen *Department of Neurology, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, No.62, Huaihai Road(S.), Huaian, 223002, Jiangsu, China.
Guokun LiuDepartment of Outpatient, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, No.62, Huaihai Road(S.), Huaian, 223002, Jiangsu, China.
Lu ZhangDepartment of Anesthesiology Operating Room, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, No.62, Huaihai Road(S.), Huaian, 223002, Jiangsu, China.
Hongyan ZhengDepartment of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, No.62, Huaihai Road(S.), Huaian, 223002, Jiangsu, China.
Jinyu ZhengDepartment of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, No.62, Huaihai Road(S.), Huaian, 223002, Jiangsu, China.
Xiaohua ZuoDepartment of Pain Management, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, No.62, Huaihai Road(S.), Huaian, 223002, Jiangsu, China.
Peng XieDepartment of Neurosurgery, The Second People's Hospital of Huai'an, The Affiliated Huai'an Hospital of Xuzhou Medical University, No.62, Huaihai Road(S.), Huaian, 223002, Jiangsu, China. bpi_971@163.com.

Funding

the Research Program of Science and Technology Support Program of Huai'an HAB2024018
6 · The paper itself

Abstract

This study probed the mechanism of MARCH6 in endoplasmic reticulum autophagy (ER-phagy) during glioma development by regulating FAM134B stability. MARCH6 and FAM134B expression levels were measured in glioma tissues. A comparative analysis was conducted on the correlation between clinical parameters and FAM134B expression in 46 glioma patients. FAM134B and MARCH6 were knocked down in glioma cells, followed by detection of cell viability and apoptosis, typical ER stress (ERS) markers (PERK, IRE1α, eIF2α, and CHOP), autophagy-related proteins (P62 and LC3B), and autophagosome cytoplasmic accumulation. A mouse glioma model was established for in vivo validation. MARCH6-FAM134B interaction, FAM134B ubiquitination levels, and protein stability were examined. FAM134B expression was high and MARCH6 expression was low in glioma tissues. MARCH6 induced FAM134B protein ubiquitination and degradation, reducing its stability in glioma cells. Knockdown of FAM134B reduced glioma cell survival, inhibited PERK, IRE1α, eIF2α, and CHOP expression, decreased LC3I to LC3II conversion, lowered LC3B fluorescence expression, and reduced the accumulation of autophagosomes with continuous ER structures in the cytoplasm, while enhancing apoptosis and P62 expression. This effect can be reversed by knocking down MARCH6. In vivo, FAM134B knockdown suppressed tumorigenesis in mice. MARCH6 exerts a repressive effect on ERS responses and ER-phagy in glioma cells by destabilizing FAM134B.

Indexed as

AutophagyBrain NeoplasmsEndoplasmic ReticulumGliomaIntracellular Signaling Peptides and ProteinsMembrane ProteinsAnimalsApoptosisCell Line, TumorCell SurvivalEndoplasmic Reticulum StressFemaleHumansMaleMiceMice, NudeIntracellular Signaling Peptides and ProteinsMembrane ProteinsRETREG1 protein, humanEndoplasmic reticulum autophagyEndoplasmic reticulum stress responseFAM134BGliomaMARCH6Ubiquitination

Identifiers

PMID41661358

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.