Evidence map›Paper›PMID 41661322›Full record

ArticleSurgery today2026

The prognostic significance and clinical application of Mac-2 binding protein glycosylation Isomer, Lectin-Reactive α-Fetoprotein Fraction, and protein induced by vitamin K Absence-II in resectable hepatocellular carcinoma.

Yoriko Nomura, Norifumi Harimoto, Kazuaki Hashimoto, Kazuki Takeishi

Abstract read
PubMed Publisher
In one paragraph

Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yoriko NomuraDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama Chuo-ku, Fukuoka, 810-8563, Japan. yorikonomura25@gmail.com.ORCID http://orcid.org/0000-0001-9876-2078
Norifumi HarimotoDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama Chuo-ku, Fukuoka, 810-8563, Japan.
Kazuaki HashimotoDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama Chuo-ku, Fukuoka, 810-8563, Japan.
Kazuki TakeishiDepartment of Hepato-Biliary-Pancreatic Surgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama Chuo-ku, Fukuoka, 810-8563, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHepatocellular carcinoma (HCC) is a major cause of cancer-related mortalities. Although hepatic resection provides favorable outcomes for resectable HCC (R-HCC), its recurrence rate remains high. This study aimed to evaluate the prognostic significance and clinical applicability of the Mac-2 binding protein glycosylation isomer (M2BPGi), lectin-reactive α-fetoprotein fraction (AFP-L3), and protein induced by vitamin K absence-II (PIVKA-II), together with tumor characteristics, in patients with R-HCC who underwent hepatic resection.

methodsWe retrospectively analyzed 250 R-HCC patients who underwent hepatic resection between 2015 and 2025 at a single institution. Preoperative biomarkers including M2BPGi, AFP-L3, and PIVKA-II, were evaluated. The primary endpoint was the disease-free survival (DFS).

resultsA multivariate analysis identified M2BPGi ≥ 1.0 (hazard ratio (HR) 2.01, p < 0.001), AFP-L3 ≥ 15% (HR, 1.84, p = 0.03), and PIVKA-II ≥ 500 mAU/mL (HR 2.44, p < 0.001) were independent predictors of recurrence. A scoring system based on the number of positive biomarkers significantly stratified DFS (P < 0.001). Patients positive for all three markers had the poorest prognoses.

conclusionsM2BPGi, AFP-L3, and PIVKA-II are independent risk factors for recurrent HCC. A simple biomarker-based scoring system offers practical guidance to hepatobiliary surgeons for tailoring postoperative surveillance and evaluating candidates for adjuvant strategies.

Indexed as

alpha-FetoproteinsAntigens, NeoplasmBiomarkersBiomarkers, TumorCarcinoma, HepatocellularLiver NeoplasmsMembrane GlycoproteinsProtein PrecursorsProthrombinAgedDisease-Free SurvivalFemaleGlycosylationHepatectomyHumansMaleacarboxyprothrombinalpha-FetoproteinsAntigens, NeoplasmBiomarkersBiomarkers, TumorMembrane GlycoproteinsProtein PrecursorsProthrombinTAA90K protein, humanBiomarkersHepatocellular carcinomaLocalNeoplasm recurrenceTumor prognosis resectable

Identifiers

PMID41661322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.