SynthesisFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
Circulating Myokine Responses to Acute Endurance Exercise and Their Role in Immunoregulation: A Systematic Review and Meta-Analysis.
Synthesis in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Circulating Myokine Responses to Acute Endurance Exercise and Their Role in Immunoregulation: A Systematic Review and Meta-Analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Pooled it
- Intensity matters: high-intensity interval resistance exercise induces greater immune activation than low-intensity resistance exercise 45 min post-workout.European journal of applied physiology · 2026Trial
- Review
- Immune Dysregulation and Persistent Symptoms: Insights into T Cell Dynamics in Post-COVID among Athletes from the CoSmo-S Study.Journal of clinical immunology · 2026Article
- Sarcopenia and sepsis fuel a self-perpetuating cycle of immunometabolism decline.Frontiers in immunology · 2026Review
- Exercise-responsive endocrine-metabolic mediators in diabetes and cardiometabolic disorders: a systematic scoping review and evidence map.Frontiers in endocrinology · 2026Article
- Divergent immune cascades activated by metabolic versus mechanical exercise intensity: revisiting cytokine heterogeneity in "moderate-intensity exercise".Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute endurance exercise influences metabolic and immune functions, with myokines playing a key role in mediating communication between these two systems and in transforming transient inflammatory signals into long-term anti-inflammatory adaptations. However, the magnitude of these anti-inflammatory effects varies widely depending on exercise type, intensity, and duration. Accordingly, the objective of this meta-analysis is to assess changes in myokine concentrations following endurance exercise and establish a potential dose-response relationship between exercise-related parameters. A systematic literature search was conducted in June 2024 for endurance exercise studies measuring changes in interleukin (IL-) 6, IL-10, IL-1ra, tumor necrosis factor (TNF-) α, IL-15, IL-7, IL-8, transforming growth factor β1, and fractalkines before and immediately after exercise in healthy individuals. Independent random-effect meta-analyses were performed for each myokine (PROSPERO: CRD42024535364). Significant small-moderate to very large positive effect sizes were observed for IL-6, IL-10, IL-1ra, IL-8, IL-15, and TNF-α. These effects were significantly moderated by risk of bias, sex, age, V̇O
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.