Evidence map›Paper›PMID 41661077›Full record

ArticleOrganic letters2026

Friedel-Crafts-Type Electrophilic Radiocyanation of (Hetero)arenes.

Casey J McCarthy, Marius Müller, Richard Ma, Umberto Maria Battisti, Jay S Wright, E William Webb, Melanie S Sanford, Matthias M Herth, Peter J H Scott

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Recent advances in [Nuclear medicine and biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Casey J McCarthyDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-3967-5705
Marius MüllerDepartment of Radiology, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0003-1882-5919
Richard MaDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Umberto Maria BattistiDrug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 160, 2100 Copenhagen, Denmark.ORCID 0000-0002-1012-8644
Jay S WrightDepartment of Radiology, University of Michigan, Ann Arbor, Michigan 48109, United States.
E William WebbDepartment of Radiology, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0003-1501-9022
Melanie S SanfordDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-9342-9436
Matthias M HerthDrug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 160, 2100 Copenhagen, Denmark.ORCID 0000-0002-7788-513X
Peter J H ScottDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-6505-0450

Funding

Synthesis of Novel PET Radiotracers for Imaging in Alzheimer’s Disease and Related DisordersR01EB021155 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SANFORD, MELANIE S., SCOTT, PETER JAMES HENRY · 2016 to 2024
$3.2M
Metal-Mediated C-H Radiofluorination for Rapid Access to PET Imaging AgentsK99EB031564 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WRIGHT, JAY SAMUEL · 2022 to 2023
$158k
NIBIB NIH HHS K99 EB031564NIBIB NIH HHS R01 EB021155
6 · The paper itself

Abstract

Radiocyanation is an attractive approach to introduce carbon-11 into radiopharmaceuticals, as nitriles and other acyl moieties. This report describes a Friedel-Crafts-type electrophilic radiocyanation of (hetero)aryltrimethylgermanes and trimethylstannanes as well as a direct C-H radiocyanation of (hetero)arenes. This approach leverages the

Identifiers

PMID41661077
PMCPMC12962353

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.