Evidence map›Paper›PMID 41661033›Full record

ArticleEuropean stroke journal2026

The MAPSTROKE analysis of the access to stroke reperfusion treatment and stroke units in Italy.

Ettore Nicolini, Antonio Ciacciarelli, Enrica Franchini, André da Silva Frainer, Leonardo da Luz Dorneles, Mateus Boiani, Marcio Dorn, Paola Santalucia, Valeria Caso, Danilo Toni and 1 more

Abstract read
In one paragraph

Article in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ettore NicoliniDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Antonio CiacciarelliStroke Unit, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Enrica FranchiniNeurologia-Stroke Unit, Ospedale Provinciale di Bolzano (SABES-ASDAA), Bolzano-Bozen, Italy.
André da Silva FrainerInstitute of Informatics and Centre for Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Leonardo da Luz DornelesInstitute of Informatics and Centre for Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.ORCID 0000-0003-4449-5570
Mateus BoianiInstitute of Informatics and Centre for Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Marcio DornInstitute of Informatics and Centre for Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Paola SantaluciaNational Centre for Clinical Governance and Excellence of Care, Italian National Institute of Health, Rome, Italy.
Valeria CasoStroke Unit, Department of Neurology, Saronno Hospital, ASST Valle Olona, Saronno, Italy.ORCID 0000-0002-2020-8891
Danilo ToniDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Leonardo Augusto CarboneraDepartment of Neurology and Neurosurgery, Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil.ORCID 0000-0002-9313-7967

Funding

Angels Initiative/Boehringer Ingelheim 782566World Stroke Organization via the Pilot Research Proposal Grant in 2022
6 · The paper itself

Abstract

backgroundAccess to reperfusion therapies and stroke unit (SU) admission remains heterogeneous across Europe. Mapping tools can reveal service gaps and guide implementation strategies. MAPSTROKE provides regional mapping of existing stroke centres and identifies potential new sites in underserved areas.

aimsTo apply a computational strategy to the Italian stroke care system to estimate national coverage for reperfusion therapies and quantify SU bed capacity under current constraints.

methodsUsing MAPSTROKE geospatial modelling, we assessed (1) 45-min access to a hospital providing reperfusion treatment and (2) SU bed coverage limited by capacity. Population and stroke incidence data for 2023 were mapped on a hexagonal grid combining sources from the Italian Ministry of Health and the Kontur Dataset. Hospitals were classified as Comprehensive (CSC), Primary (PSC), Acute Stroke-Ready (ASRH) or Potential Acute Stroke Centres (PASC). Isochrones of 45 min were generated for hospitals performing reperfusion. Regional coverage was estimated, and a Partial Set Covering identified the minimal number of PASCs required to achieve ≥ 90% coverage. Stroke unit capacity was estimated using bed counts and mean length of stay (LOS).

resultsAmong 535 hospitals (80 CSCs, 132 PSCs, 22 ASRHs, 301 PASCs), 91.7% of strokes were within 45 min of a hospital providing reperfusion treatment. Seven regions were below 90%, 6 achieved this target after optimisation. National SU capacity covered 79.2% of annual incidence, with a gap of 255 beds (158 with ideal LOS).

conclusionsThe MAPSTROKE project reveals adequate reperfusion access but critical SU capacity disparities, underscoring the need for coordinated national strategies.

Indexed as

Health Services AccessibilityHospital UnitsReperfusionStrokeHospitalsHumansItalyalgorithmsgeographic information systemshealthcare planninghealth services accessibilitymedical informaticsstroke

Identifiers

PMID41661033
PMCPMC12884559

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.