Evidence map›Paper›PMID 41660927›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2026

A Multidimensional Assessment of the Aperture Shape Controller in VMAT for Ca Tongue: Implications for Plan Complexity and Quality Assurance.

Ajithkumar M, Subhankar Show, Sneha Jha, Aaditya Prakash, Chitra S

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Article in Asian Pacific journal of cancer prevention : APJCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Ajithkumar MDepartment of Radiotherapy, Meherbai Tata Memorial Hospital, Jamshedpur, India.ORCID 0000-0002-7137-841X
Subhankar ShowDepartment of Radiotherapy, Meherbai Tata Memorial Hospital, Jamshedpur, India.
Sneha JhaDepartment of Radiotherapy, Meherbai Tata Memorial Hospital, Jamshedpur, India.
Aaditya PrakashDepartment of Radiotherapy, Tata Main Hospital, Jamshedpur, India.
Chitra SDepartment of Radiotherapy, Meherbai Tata Memorial Hospital, Jamshedpur, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to evaluate the impact of varying Aperture Shape Controller (ASC) settings on the optimization of VMAT plans for tongue carcinoma (Ca-Tongue), focusing on their role in modulating plan complexity, maintaining dosimetric integrity, and ensuring accurate treatment delivery. MATERIALS AND

methodsTwenty Ca-Tongue patients were retrospectively planned using four ASC settings: Off, Very Low, Moderate, and Very High, totaling 80 plans. Complexity metrics such as Modulation Complexity Score (MCSv), Small Aperture Score (SAS), and Monitor Units per cGy (MU/cGy) were computed using MATLAB from exported DICOM RT files. Each plan underwent portal dosimetry QA with gamma analysis (3%/3mm and 2%/2mm). Dosimetric quality was evaluated using Conformity Index (CI), Homogeneity Index (HI), and PTV D98%, along with doses to organs-at-risk (OARs). Statistical analysis included the Wilcoxon signed-rank test and linear regression.

resultsIncreasing ASC level significantly reduced plan complexity: MCSv increased from 0.32±0.02 (Off) to 0.38±0.03 (Very High), SAS decreased from 0.47±0.04 to 0.37±0.07, and MU/cGy dropped from 2.25±0.09 to 2.03±0.12 (p < 0.05). However, higher ASC levels were associated with minor but consistent reductions in PTV coverage (D98%: 96.66% to 94.94%) and increases in OAR doses (e.g., spinal cord Dmax: 30.46 Gy to 34.90 Gy). CI and HI remained clinically acceptable across all settings. Gamma pass rates were uniformly high (≥98.85%), with no significant improvement across ASC levels. Weak or negligible correlations (R² <  0.323) were found between complexity metrics and gamma outcomes.

conclusionThe ASC effectively reduces plan complexity in VMAT for Ca-Tongue without compromising delivery accuracy. While Very High ASC yields the greatest complexity reduction, it also introduces modest trade-offs in PTV coverage and OAR sparing. The Moderate ASC setting appears optimal, offering a balance between complexity control and dosimetric quality. Clinical implementation of ASC should be tailored to tumor site and anatomy, with Moderate ASC recommended for head and neck VMAT to ensure safety, efficiency, and robust QA performance.

Indexed as

Quality Assurance, Health CareRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedTongue NeoplasmsHumansOrgans at RiskPrognosisRadiometryRadiotherapy DosageRetrospective StudiesDose Modulationhead and neck cancerPortal dosimetryRadiotherapy OptimizationTreatment Delivery Efficiency

Identifiers

PMID41660927
PMCPMC13499580

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.