Evidence map›Paper›PMID 41660903›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2026

Mitogen-Activated Protein Kinase-3 (MAPK3) Is the Main Target of Microsecond Pulsed Electric Field in Human Medulloblastoma.

Ayad Bahadorimonfared, Zahra Razzaghi, Reza M Robati, Babak Arjmand, Naybali Ahmadi, Nastaran Asri, Aliasghar Keramatinia, Farideh Razi, Fatemeh Bandarian

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Article in Asian Pacific journal of cancer prevention : APJCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ayad BahadorimonfaredDepartment of Health & Community Medicine, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zahra RazzaghiLaser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reza M RobatiSkin Research Center, Shahid Beheshti University of medical sciences, Tehran, Iran.ORCID 0000-0002-7947-8642
Babak ArjmandCell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-5001-5006
Naybali AhmadiProteomics Research Center, System Biology Institute, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nastaran AsriCeliac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Aliasghar KeramatiniaDepartment of Community Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Farideh RaziDiabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh BandarianEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPulsed electric fields (PEFs) are applied to facilitate the transfer of various types of molecules, such as pharmaceuticals, into living cells. In the present study effect of microsecond PEF on human medulloblastoma cell line (D283Med cells) is investigated to find the crucial targeted genes.

methodsGene expression profiles of the human medulloblastoma (D283) cell line in response to microsecond PEF versus control are extracted from the Gene Expression Omnibus (GEO) database. The samples are analyzed via the GEO2R program to find the significant differentially expressed genes (DEGs). The significant DEGs were assessed via protein-protein interaction (PPI) network using Cytoscape software and its applications.

resultsAmong 410 significant DEGs, 23 hubs and bottlenecks were determined. A total number of seven hub-bottlenecks including MAPK3, KIT, APP, RUNX2, CXCR4, LMNA, and BMP4 were pointed out as the crucial targets of microsecond PEF. MAPK3 and KIT were down-regulated while, APP, RUNX2, CXCR4, LMNA, and BMP4 were up-regulated.

conclusionIt can be concluded that, down-regulation of MAPK3 and KIT and up-regulation of BMP4 which are the consequence of microsecond PEF treatment inhibit medulloblastoma. The results exhibited the significant role of MAPK3 in response to microsecond PEF treatment.

Indexed as

Cerebellar NeoplasmsGene Expression Regulation, NeoplasticMedulloblastomaMitogen-Activated Protein Kinase 3Cell Line, TumorElectroporation TherapiesGene Expression ProfilingHumansProtein Interaction MapsTumor Cells, CulturedMAPK3 protein, humanMitogen-Activated Protein Kinase 3cancer cell linegene expression profilingMAPK3medulloblastomaMicrosecond pulsed electric fields

Identifiers

PMID41660903
PMCPMC13499617

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.