Evidence map›Paper›PMID 41660859›Full record

ArticlemBio2026

HCMV promotes viral reactivation through the coordinated regulation of Notch signaling by UL8 and miR-UL36.

Aaron Dirck, Nicole Diggins, Wilma Perez, Christopher Parkins, Michael Daily, Rebekah L Turner, Luke Slind, Linh Nguyen, Daniel Malouli, Guanming Wu and 2 more

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Aaron DirckVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Nicole DigginsVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.ORCID 0000-0001-8007-7865
Wilma PerezVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Christopher ParkinsVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Michael DailyVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Rebekah L TurnerVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.ORCID 0000-0003-2516-0353
Luke SlindVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Linh NguyenVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Daniel MalouliVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.
Guanming WuDivision of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Meaghan HancockVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.ORCID 0000-0003-2945-0147
Patrizia CaposioVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, USA.ORCID 0000-0001-7579-849X

Funding

The Administrative CoreP01AI127335 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Patrizia Caposio · 2017 to 2026
$24.6M
MOLECULAR ASPECTS OF CYTOMEGALOVIRUS LATENCYR01AI021640 · NIAID · UNIVERSITY OF GUELPH · PI Meaghan H Hancock · 1985 to 2026
$8.1M
Molecular Aspects of Cytomegalovirus LatencyR37AI021640 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HANCOCK, MEAGHAN H · 2018 to 2024
$4.0M
Interdisciplinary Training in Microbial Pathogenesis and ImmunologyT32AI170496 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Patrizia Caposio, Scott M Landfear · 2023 to 2026
$1.5M
NIAID NIH HHS P01 AI127335NIAID NIH HHS R01 AI021640NIAID NIH HHS R37 AI021640NIAID NIH HHS T32 AI170496
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) establishes latency in CD34

Indexed as

CytomegalovirusHost-Pathogen InteractionsMicroRNAsReceptors, NotchSignal TransductionViral ProteinsVirus ActivationAnimalsCytomegalovirus InfectionsHematopoietic Stem CellsHumansImmunoglobulin J Recombination Signal Sequence-Binding ProteinMiceVirus LatencyImmunoglobulin J Recombination Signal Sequence-Binding ProteinMicroRNAsReceptors, NotchViral Proteinshuman cytomegalovirusmiR-UL36Notch signalingpUL8viral reactivation

Identifiers

PMID41660859
PMCPMC12977634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.