Evidence map›Paper›PMID 41660850›Full record

ArticleMicrobiology spectrum2026

Genetic basis of cefiderocol resistance in

Kevin J Rome, José R Mediavilla, Austin J Terlecky, Mia J Bucich, Elena Shashkina, Jianping Jiang, Dillon Kunkle, Albert Rojtman, Eric Skaar, Liang Chen and 1 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. High-Resolution Genomic Surveillance of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kevin J RomeCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-2262-4813
José R MediavillaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Austin J TerleckyCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Mia J BucichCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Elena ShashkinaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Jianping JiangCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Dillon KunkleVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Albert RojtmanCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Eric SkaarVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-5094-8105
Liang ChenSchool of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA.ORCID 0000-0001-5845-2235
Barry N KreiswithCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-0243-131X

Funding

Host-mediated zinc sequestration during Acinetobacter baumannii infectionR01AI101171 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALTER J. CHAZIN, DAVID P. GIEDROC · 2013 to 2026
$8.2M
NIH HHS R01AI101171
6 · The paper itself

Abstract

Cefiderocol (CFDC) is a siderophore-conjugated cephalosporin that hijacks bacterial iron uptake pathways to traverse the outer membrane, offering potent activity against carbapenem-resistant

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial AgentsCephalosporinsBacterial ProteinsCefiderocolDNA Transposable ElementsGenomicsHumansIronMicrobial Sensitivity TestsMutationAnti-Bacterial AgentsBacterial ProteinsCefiderocolCephalosporinsDNA Transposable ElementsIronantimicrobial resistancecarbapenem-resistant Acinetobacter baumanniicefiderocolcomparative genomicsiron metabolismtransposon mutagenesiswhole-genome sequencing

Identifiers

PMID41660850
PMCPMC12955420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.