ArticleMicrobiology spectrum2026
Biochemical and structural analyses of metallo-β-lactamase VIM-28: impact of substitutions at residues 224 and 228 on substrate profile, stability, and zinc affinity.
Hiromu Sato, Nao Ishizawa, Ryo-Ya Koto, Kaisei Hiura, Hiyori Saito, Yoshiki Kato, Nancy D Hanson, Yoshikazu Ishii, Akiko Shimizu-Ibuka
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In one paragraphArticle in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Hiromu SatoDepartment of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
Nao IshizawaDepartment of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
Ryo-Ya KotoDepartment of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
Kaisei HiuraDepartment of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
Hiyori SaitoDepartment of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
Yoshiki KatoDepartment of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
Nancy D HansonDepartment of Medical Microbiology and Immunology, Creighton University, Omaha, Nebraska, USA.
Yoshikazu IshiiDepartment of Microbial Genomics and Ecology, Center for the Planetary Health and Innovation Science, The IDEC Institute, Hiroshima University, Higashi-Hiroshima City, Hiroshima, Japan.ORCID 0000-0002-1943-4648 Akiko Shimizu-IbukaDepartment of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.ORCID 0000-0002-5310-9216 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Metallo-β-lactamases (MBLs) hydrolyze a broad range of β-lactams, including carbapenems. VIM-28, an MBL identified in
Indexed as
Bacterial Proteinsbeta-LactamasesPseudomonas aeruginosaZincAmino Acid SubstitutionAmpicillinAnti-Bacterial Agentsbeta-LactamsCarbapenemsCeftazidimeEnzyme StabilityKineticsMicrobial Sensitivity TestsSubstrate SpecificityThird Generation CephalosporinsAmpicillinAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasesbeta-LactamsCarbapenemsCeftazidimeThird Generation CephalosporinsZincantibiotic resistancemetallo-β-lactamaseszinc
Identifiers
PMID41660846
PMCPMC12955476
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