Evidence map›Paper›PMID 41660661›Full record

ArticleOpen forum infectious diseases2026

C-Reactive Protein for Pulmonary Tuberculosis Screening and Treatment Response Monitoring in Children.

Joy Githua, Jerphason Mecha, Joshua Stern, Jaclyn N Escudero, Lilian Njagi, Lucy Kijaro, Jacqueline Mirera, Wilfred Murithi, Grace John-Stewart, Elizabeth Maleche-Obimbo and 2 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Joy GithuaCentre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.ORCID https://orcid.org/0009-0007-3295-2275
Jerphason MechaCentre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.ORCID https://orcid.org/0009-0008-6446-0395
Joshua SternDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Jaclyn N EscuderoDepartment of Global Health, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-3513-774X
Lilian NjagiCentre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.ORCID https://orcid.org/0000-0002-5067-0788
Lucy KijaroCentre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.
Jacqueline MireraCentre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.ORCID https://orcid.org/0009-0008-7580-8422
Wilfred MurithiCentre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.ORCID https://orcid.org/0000-0002-4495-2957
Grace John-StewartDepartment of Global Health, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-4301-1573
Elizabeth Maleche-ObimboDepartment of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.ORCID https://orcid.org/0000-0001-7871-3367
Videlis NdubaCentre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.
Sylvia M LaCourseDepartment of Global Health, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-9809-5997

Funding

CRISPR-TB for pediatric TB diagnosis and treatment responseR01AI179714 · NIAID · UNIVERSITY OF WASHINGTON · PI Sylvia LaCourse · 2024 to 2026
$2.2M
NIAID NIH HHS R01 AI179714
6 · The paper itself

Abstract

C-reactive protein (CRP) was evaluated as a biomarker for pulmonary tuberculosis (TB) diagnosis and treatment response monitoring in 292 Kenyan children. Although diagnostic sensitivity was suboptimal (35.5%-50.0%), the median CRP level decreased during TB treatment in children with confirmed (

Indexed as

C-reactive proteindiagnosispediatrictreatment responsetuberculosis

Identifiers

PMID41660661
PMCPMC12872367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.