Evidence map›Paper›PMID 41660628›Full record

ArticleFrontiers in immunology2025

Sphingosine kinase 2 suppresses neutrophil responses to promote viral persistence while attenuating immune pathology.

Vijayamahantesh Vijayamahantesh, Ying He, Lei Jiang, Hailey Huerter, Kwang Il Jung, Savannah McKenna, Caleb J Studstill, Lee-Ann H Allen, Ravi Nistala, Dong Xu and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vijayamahantesh VijayamahanteshDepartments of Surgery and Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, United States.
Ying HeDepartments of Surgery and Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, United States.
Lei JiangDepartment of Electrical Engineering and Computer Science, and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, United States.
Hailey HuerterDepartments of Surgery and Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, United States.
Kwang Il JungDepartments of Surgery and Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, United States.
Savannah McKennaDepartments of Surgery and Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, United States.
Caleb J StudstillDepartments of Surgery and Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, United States.
Lee-Ann H AllenDepartment of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, United States.
Ravi NistalaDivision of Nephrology, Department of Medicine, University of Missouri, Columbia, MO, United States.
Dong XuDepartment of Electrical Engineering and Computer Science, and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, United States.
Bumsuk HahmDepartments of Surgery and Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, United States.

Funding

Interplay between influenza virus and S1P-metabolizing enzymesR01AI162631 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI HAHM, BUMSUK · 2021 to 2025
$2.2M
Regulation of host immunity to impact virus persistenceR01AI153076 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI HAHM, BUMSUK · 2021 to 2025
$2.1M
NIAID NIH HHS R01 AI153076NIAID NIH HHS R01 AI162631
6 · The paper itself

Abstract

Chronic viral infections often suppress immune cell functions, which helps restrict immune pathology but leads to viral persistence. However, the underlying mechanisms are not completely understood. We recently found that sphingosine kinase 2 (SphK2)-deficient (

Indexed as

Lymphocytic ChoriomeningitisLymphocytic choriomeningitis virusNeutrophilsPhosphotransferases (Alcohol Group Acceptor)AnimalsMiceMice, KnockoutSphingosine KinaseT-LymphocytesPhosphotransferases (Alcohol Group Acceptor)Sphingosine Kinasesphingosine kinase 2, mouseimmune suppressionneutrophil regulationsphingosine kinaseT cell regulationvirus persistence

Identifiers

PMID41660628
PMCPMC12872563

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.