ArticleFrontiers in immunology2025
Non-human primate preclinical model revealed the feasibility and short-term safety of iPSC-derived innate-like T cells in autologous transplantation.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
11 authors.
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Abstract
Background: T cells derived from gene-edited induced pluripotent stem cells (iPSCs) are a promising alternative cell source for universal T-cell immunotherapy. However, current preclinical evaluations of iPSC-derived T cells (iPSC-T cells) rely on immunodeficient mouse models, which limit the assessment of immune-related adverse events and in vivo immune cell interactions. Methods: To overcome these limitations, we developed a preclinical nonhuman primate model to evaluate the safety and cellular kinetics of iPSC-T cells. iPSCs were generated from peripheral blood T cells obtained from two rhesus macaques and redifferentiated in vitro into CD8αβ Results: The iPSC-T cells exhibited both antigen-dependent and antigen-independent cytotoxicity and demonstrated robust proliferative capacity upon repeated stimulation. Stable GFP expression was maintained during cell expansion. Following autologous infusion, no safety concerns were observed for up to one year after the first administration. Cellular kinetic analyses revealed that the infused iPSC-T cells trafficked to the alveolar space and were no longer detectable in peripheral circulation by seven days post-infusion. Conclusion: These findings establish a unique immunocompetent primate model for assessing the safety and
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