Exosome-mediated bidirectional immune dysregulation in tuberculosis: proteomic profiling reveals strain-specific strategies of virulent H37Rv and attenuated H37Ra.

Xiuli Zhang, Wenxia Ma, Yuzhu Zheng, Lingna Lyu

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

4 authors.

Xiuli Zhang *Department of Gastroenterology and Hepatology, Laboratory for Clinical Medicine, Beijing You'an Hospital Affiliated to Capital Medical University, Beijing, China.

Wenxia Ma *Department of Gastroenterology and Hepatology, Laboratory for Clinical Medicine, Beijing You'an Hospital Affiliated to Capital Medical University, Beijing, China.

Yuzhu ZhengDepartment of Gastroenterology and Hepatology, Laboratory for Clinical Medicine, Beijing You'an Hospital Affiliated to Capital Medical University, Beijing, China.

Lingna LyuDepartment of Gastroenterology and Hepatology, Laboratory for Clinical Medicine, Beijing You'an Hospital Affiliated to Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Tuberculosis (TB), caused by Methods: This study employed iTRAQ-based proteomics to dissect strain-specific immune modulation strategies of virulent H37Rv (RV) and attenuated H37Ra (RA) through macrophage and exosome profiling. Results: We revealed distinct survival strategies of Discussion: Conclusively, Mtb exploits exosomes as "virulence vectors" to deliver RhoGDI and death signals (e.g., Caspse-9), paralyzing systemic immunity while optimizing intracellular survival. Virulence-specific cargo sorting informs novel diagnostics and therapies against TB. However, given the limitations of the in vitro model, future research should incorporate in vivo models and clinical trials to validate these findings.

Indexed as

ExosomesMacrophagesMycobacterium tuberculosisTuberculosisAnimalsBacterial ProteinsHost-Pathogen InteractionsHumansProteomicsVirulenceBacterial Proteinsexosomesimmune evasionmacrophagemycobacterium tuberculosisproteomicsstrain virulence

Identifiers

PMID41660623

DOI10.3389/fimmu.2025.1696299

PMCPMC12876188

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