Evidence map›Paper›PMID 41660622›Full record

ReviewFrontiers in immunology2025

Emerging diagnostic and therapeutic opportunities in food allergy.

Lukas Michaja Balsiger, Oliver M Würgler, Hugh A Sampson, Alexander Eggel

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lukas Michaja BalsigerDepartment for BioMedical Research, University of Bern, Bern, Switzerland.
Oliver M WürglerDepartment for BioMedical Research, University of Bern, Bern, Switzerland.
Hugh A SampsonSeren & John Liew Division of Pediatric Allergy/Immunology, Icahn School of Medicine at Mount Sinai, Jaffe Food Allergy Institute, New York, NY, United States.
Alexander EggelDepartment for BioMedical Research, University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food allergy is characterized by acute onset of symptoms affecting multiple organ systems following the ingestion of otherwise innocuous food antigens. The prevalence of this potentially life-threatening disease is globally increasing and poses a significant burden on society and healthcare systems. In this review, we summarize the pathophysiology of food allergy focusing on pre-clinical evidence of how oral tolerance is broken and the role of systemic and mucosal immunoglobulin E (IgE) in food allergy. Diagnosing food allergy is complex and requires a multimodal approach. Importantly, the diagnostic accuracy of currently available tests is variable, and

Indexed as

Food HypersensitivityAllergensAnaphylaxisAnimalsHumansImmune ToleranceImmunoglobulin EMast CellsAllergensImmunoglobulin Eanti-IgEbasophilsbead-based epitope assaydiagnosisfood allergyIgEmast cell activation testmast cells

Identifiers

PMID41660622
PMCPMC12872576

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.