Evidence map›Paper›PMID 41660568›Full record

ArticleNational science review2026

Emerging local chikungunya virus transmission in a major urban area in Southern China: characteristics of clinical manifestations, viral evolution and climatic influences.

Jingyi Liang, Haisheng Yu, Zhengshi Lin, Xi Tang, Zhonghao Fang, Chitin Hon, Wenxin Hong, Lesi Kong, Yurou Wang, Yiwen Chen and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in National science review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Jingyi LiangInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China.ORCID https://orcid.org/0000-0002-0450-552X
Haisheng YuInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China.ORCID https://orcid.org/0000-0002-1757-1411
Zhengshi LinState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Xi TangDepartment of infectious disease, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), Foshan 500062, China.
Zhonghao FangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Chitin HonDepartment of Engineering Science, Faculty of innovation Engineering, Macau University of Science and Technology, Taipa, Macau 999078, China.
Wenxin HongInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China.
Lesi KongState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Yurou WangInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China.
Yiwen ChenInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China.
Yuepeng LiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Yuelin ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Minling GuoInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China.
Shan WuInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China.
Fengyu HuInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China.ORCID https://orcid.org/0000-0002-8649-7913
Haoran QiuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Honglian BaiDepartment of infectious disease, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), Foshan 500062, China.
Haiming YanDepartment of infectious disease, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), Foshan 500062, China.
Suhua JiangDepartment of infectious disease, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), Foshan 500062, China.
Qingsen ZhangDepartment of infectious disease, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), Foshan 500062, China.
Jinfeng LiuDepartment of infectious disease, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), Foshan 500062, China.
Huiling ZhouDepartment of infectious disease, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), Foshan 500062, China.
Menglin TanDepartment of infectious disease, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), Foshan 500062, China.
Weijun HuangDepartment of infectious disease, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), Foshan 500062, China.
Arlindo OliveiraINESC-ID, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal.
Jun JiangDepartment of infectious disease, The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), Foshan 500062, China.
Yihui HuangInstitute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510440, China.
Zifeng YangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.
Nanshan ZhongState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 2025 chikungunya fever outbreak in Foshan, China rapidly spread from a previously non-endemic area, raising significant public health concerns. This event underscores the need to understand the factors driving viral transmission, host responses and the influence of local environmental changes. The primary objectives of this study were to: (i) characterize the clinical manifestations of chikungunya patients at the initial stage of the outbreak to facilitate concise diagnosis and treatment; (ii) determine the viral genetic factors contributing to the outbreak's rapid spread; and (iii) investigate the influence of local environmental and climatic conditions on vector mosquito reproduction. We quickly collected and analyzed clinical data from 134 patients hospitalized for the purpose of quarantine at the beginning of the outbreak. While fever, arthralgia and rash are the typical symptom triad of chikungunya fever, we found that they did not always present simultaneously at onset. Arthralgia was the most common presenting symptom. Phylogenetic analysis revealed that the viral strains were highly homologous to those from the Réunion outbreak, suggesting an imported origin. Furthermore, we identified the presence of E1-A226V, E2-I211T and E2-L210Q mutations, which have been previously associated with enhanced transmission by

Indexed as

chikungunya feverclimateclinical characteristictransmissionvirus

Identifiers

PMID41660568
PMCPMC12878321

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.