Evidence map›Paper›PMID 41660553›Full record

ArticleHuman mutation2026

Buyang Huanwu Decoction Alleviates Chronic Intermittent Hypoxia-Induced Myocardial Inflammation and Fibrosis via the NF-

Lijun Ou, Chenyi Liu, Weicheng Zhao, Cairu Liu, Ye Ning, Minghua Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lijun OuDepartment of Cardiovascular Disease, The Fourth Clinical College of Guangzhou University of Traditional Chinese Medicine/Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.ORCID https://orcid.org/0009-0005-5522-7100
Chenyi LiuEmergency Department, Shenzhen Luohu Hospital of Traditional Chinese Medicine, Shenzhen, China.ORCID https://orcid.org/0000-0002-0387-418X
Weicheng ZhaoDepartment of Cardiovascular Disease, The Fourth Clinical College of Guangzhou University of Traditional Chinese Medicine/Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.ORCID https://orcid.org/0009-0009-5972-1084
Cairu LiuDepartment of Cardiovascular Disease, The Fourth Clinical College of Guangzhou University of Traditional Chinese Medicine/Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.ORCID https://orcid.org/0009-0008-3529-173X
Ye NingDepartment of Cardiovascular Disease, The Fourth Clinical College of Guangzhou University of Traditional Chinese Medicine/Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.ORCID https://orcid.org/0009-0008-9606-6587
Minghua RenDepartment of Cardiovascular Disease, The Fourth Clinical College of Guangzhou University of Traditional Chinese Medicine/Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the protective effects of Buyang Huanwu decoction (BYHW) on myocardial injury induced by chronic intermittent hypoxia (CIH) in rats and to analyze its potential regulatory mechanism through the NF- Methods: Then, 36 adult male Sprague-Dawley (SD) rats (weighing 200-250 g) were randomly divided into six groups ( Results: Compared with the NC group, rats exposed to CIH or LPS showed elevated blood pressure and an increased heart rate, along with impaired cardiac function, as evidenced by reduced LVEF ( Conclusion: BYHW improves cardiac function and reduces myocardial inflammation and fibrosis in SD rats with CIH. This effect may be related to the inhibition of the NF-

Indexed as

Drugs, Chinese HerbalHypoxiaInflammationMyocardiumNF-kappa BSignal TransductionAnimalsDisease Models, AnimalFibrosisMaleRatsRats, Sprague-Dawleybuyang huanwuDrugs, Chinese HerbalNF-kappa BBuyang Huanwu decoction (BYHW)cardiac functionchronic intermittent hypoxia (CIH)Lysyl oxidase (LOX)myocardial fibrosisnuclear factor-kappa B (NF-)

Identifiers

PMID41660553
PMCPMC12877324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.